L-Dopa-2,5,6-d3 | CAS 53587-29-4

OVERVIEW  of  L-Dopa-2,5,6-d3 | CAS 53587-29-4

L-Dopa-2,5,6-d3 (CAS 53587-29-4) is a deuterium-labeled isotopologue of L-Dopa, containing three deuterium atoms positioned on the aromatic ring. As a key biochemical precursor of dopamine, norepinephrine, and epinephrine, L-Dopa is central to neurological, pharmacokinetic, and metabolic research.
The deuterated analog, L-Dopa-2,5,6-d3, provides enhanced mass differentiation for LC-MS/MS assays, enabling precise quantitation of L-Dopa and its metabolites in plasma, tissues, and brain samples. This compound is highly valuable for neurochemical studies, Parkinson’s disease research, drug metabolism investigations, and isotope-dilution mass spectrometry. Manufactured with high chemical and isotopic purity, L-Dopa-2,5,6-d3 from ResolveMass Laboratories Inc. supports advanced pharmaceutical and clinical analytical workflows.

CHEMICAL INFORMATION
Chemical Name: L-Dopa-2,5,6-d3
Synonyms: Deuterated L-DOPA; L-3,4-dihydroxyphenylalanine-d3
CAS Number: 53587-29-4
Molecular Formula: C₉H₈D₃NO₄
Molecular Weight: 200.21 g/mol
Isotopic Enrichment: ≥98 atom % D

APPLICATIONS  of  L-Dopa-2,5,6-d3 | CAS 53587-29-4

• Neurological & Neurochemical Research: Essential for studying dopamine biosynthesis, neurotransmitter balance, and neurodegenerative disease mechanisms.

• LC-MS/MS Quantification: Used as a stable isotope internal standard for accurate measurement of L-Dopa in biological matrices.

• Parkinson’s Disease Research: Supports PK/PD studies, therapeutic drug monitoring, and metabolic profiling in preclinical and clinical models.

• Metabolic Pathway Analysis: Enables tracing of catecholamine metabolism and oxidative degradation processes.

• Pharmaceutical R&D: Useful in stability testing, impurity profiling, and drug interaction studies involving L-Dopa formulations.

• Clinical Diagnostics: Supports bioanalytical assays for evaluating treatment response and neurotransmitter imbalances.

FEATURES & BENEFITS

• Precise Isotopic Labeling: Three deuterium atoms ensure strong mass separation for high-accuracy MS analysis.

• High Purity & Stability: Suitable for sensitive neurochemical and clinical quantitative applications.

• Biological Relevance: Structurally equivalent to native L-Dopa, ensuring accurate metabolic and pharmacokinetic behavior.

• Versatile Analytical Compatibility: Effective in LC-MS/MS, GC-MS (after derivatization), and NMR applications.

• Ideal for Regulated Laboratories: Meets stringent requirements for pharmaceutical and clinical workflows.

SUMMARY
L-Dopa-2,5,6-d3 (CAS 53587-29-4) is a high-purity deuterated derivative of L-Dopa used in neurochemical research, LC-MS/MS quantitation, Parkinson’s disease studies, and metabolic pathway analysis. With three deuterium atoms allowing clear isotopic differentiation, it provides exceptional precision for pharmacokinetic, biochemical, and clinical assays.

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