Malathion-d9 (dimethyl-d6; 2,2,3-d3) | CAS 1189877-72-2.

OVERVIEW  of  Malathion-d9 (dimethyl-d6; 2,2,3-d3) | CAS 1189877-72-2.
Malathion-d₉ (dimethyl-d₆; 2,2,3-d₃) is a fully deuterium-labeled analog of the widely used organophosphate insecticide malathion. In this isotopically labeled compound, both methyl groups of the thiophosphate moiety are replaced with deuterium atoms (six deuteriums), and three additional deuteriums are introduced on the ethyl substituent (2,2,3-d₃), resulting in a total of nine deuterium atoms. This isotopic substitution increases the molecular weight by +9 Da compared to native malathion, without altering its chemical structure or biological characteristics.

Malathion-d₉ serves as a highly precise internal standard for mass spectrometry (MS) and chromatographic analyses (GC-MS, LC-MS/MS). It is extensively employed in pesticide residue quantification, toxicological studies, and environmental fate analysis of organophosphorus compounds.

CHEMICAL INFORMATION

• Name: Malathion-d₉

• Molecular Formula: C₁₀H₁₀D₉O₆PS₂

• Molecular Weight: 339.40 g/mol

• CAS Number: 1189877-72-2

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated organophosphate insecticide analog

• Stability: Stable under inert and dry conditions; hydrolyzes slowly in alkaline environments

APPLICATIONS  of  Malathion-d9 (dimethyl-d6; 2,2,3-d3) | CAS 1189877-72-2.

• Mass Spectrometry and Chromatography:
  Malathion-d₉ is used as a deuterated internal standard in LC-MS/MS and GC-MS methods for quantitative analysis of malathion residues. The +9 Da isotopic shift allows for clear differentiation between labeled and unlabeled species, ensuring precise quantification in complex matrices.

• Environmental and Agricultural Studies:
  Utilized as a stable isotope tracer to investigate biodegradation pathways, persistence, and environmental fate of malathion in soil, water, and agricultural products.

• Toxicology and Metabolic Research:
  Serves in biomonitoring and metabolic profiling to study the absorption, distribution, and breakdown of organophosphate pesticides in biological systems.

• Analytical Method Development:
  Provides a reliable reference material for validation, calibration, and quality control of pesticide residue analysis procedures.

ADVANTAGES  of  Malathion-d9 (dimethyl-d6; 2,2,3-d3) | CAS 1189877-72-2.

• High isotopic enrichment ensures strong isotopic resolution in MS-based detection.

• Chemically identical to malathion, ensuring analytical comparability and reproducibility.

• Non-radioactive and safe for laboratory use.

• Ideal for environmental trace studies and metabolic investigations.

• Enhances quantitative precision in isotope dilution assays.

HANDLING, STORAGE & SAFETY

• Hazards: Organophosphate compounds are toxic; they act as cholinesterase inhibitors, posing risks if inhaled, ingested, or absorbed through the skin.

• Precautions: Handle only under a fume hood. Use gloves, goggles, and protective lab attire. Avoid contact, inhalation, or ingestion.

• Storage: Keep in tightly sealed amber glass containers, under inert gas, at 2–8 °C. Avoid exposure to sunlight and humidity.

• Disposal: Dispose of according to environmental and hazardous waste regulations for organophosphate compounds.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Verification Methods: Confirmed by GC-MS, LC-MS, and NMR (¹H and ²H NMR verifying full deuterium incorporation).

• Appearance: Clear to light yellow liquid

• Documentation: Certificate of Analysis (CoA) provided with isotopic and purity data

SUMMARY
Malathion-d₉ (dimethyl-d₆; 2,2,3-d₃) | CAS 1189877-72-2 is a deuterium-labeled organophosphate analog designed for quantitative mass spectrometric and environmental analyses. With nine deuterium substitutions providing clear isotopic distinction, this compound enables accurate residue quantification, metabolic tracing, and environmental monitoring of malathion and related organophosphates. Its high isotopic purity, chemical stability, and analytical performance make it an essential standard for laboratories specializing in pesticide analysis, toxicology, and regulatory testing.