N-Methylpiperazine-2,2,3,3,5,5,6,6-d8 | CAS 917358-65-7

OVERVIEW  of  N-Methylpiperazine-2,2,3,3,5,5,6,6-d8 | CAS 917358-65-7

N-Methylpiperazine-2,2,3,3,5,5,6,6-d₈ (CAS 917358-65-7) is a ring-deuterated analog of N-methylpiperazine, featuring eight deuterium atoms substituted for hydrogen atoms on the piperazine ring. This stable isotope-labeled compound retains the full structural and chemical behavior of its non-deuterated counterpart while offering enhanced analytical precision. It is widely employed in mass spectrometry (MS), nuclear magnetic resonance (NMR), metabolomics, and pharmaceutical research for tracing, quantification, and mechanistic studies of piperazine derivatives and drug metabolites.

CHEMICAL INFORMATION

• Name: N-Methylpiperazine-2,2,3,3,5,5,6,6-d₈

• Molecular Formula: C₅H₃D₈N₂

• Molecular Weight: 108.21 g/mol

• CAS Number: 917358-65-7

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic amine

• Solubility: Miscible with water, alcohols, and common organic solvents

APPLICATIONS  of  N-Methylpiperazine-2,2,3,3,5,5,6,6-d8 | CAS 917358-65-7

• Mass Spectrometry (MS):
  N-Methylpiperazine-2,2,3,3,5,5,6,6-d₈ serves as an internal standard in LC-MS/MS analyses, ensuring high accuracy and reproducibility in the quantification of N-methylpiperazine and its related metabolites.

• NMR Spectroscopy:
  Its deuterated structure minimizes background proton signals, enhancing resolution and simplifying spectral interpretation in complex mixtures.

• Pharmaceutical Research and Drug Metabolism Studies:
  Commonly used in bioanalytical method development and pharmacokinetic investigations, this isotope-labeled compound aids in identifying metabolic pathways, assessing drug stability, and quantifying residual piperazine intermediates in formulations.

• Isotope Tracing and Mechanistic Studies:
  Deuterium incorporation provides a tool for tracking chemical transformations and studying reaction kinetics, including hydrogen-deuterium exchange and enzyme-catalyzed processes.

• Synthetic Chemistry:
  Employed as a deuterated building block for the synthesis of isotopically labeled derivatives, intermediates, and standards in pharmaceutical and organic synthesis.

ADVANTAGES  of  N-Methylpiperazine-2,2,3,3,5,5,6,6-d8 | CAS 917358-65-7

• High isotopic purity and chemical stability.

• Non-radioactive, environmentally safe isotope label.

• Accurate reference standard for LC-MS/MS and NMR applications.

• Excellent choice for mechanistic and pharmacokinetic investigations.

• Compatible with aqueous and organic systems due to solubility versatility.

HANDLING AND SAFETY

• Handling: Use in well-ventilated laboratory conditions. Avoid inhalation, ingestion, and prolonged skin contact.

• Protective Equipment: Wear gloves, lab coat, and eye protection during handling.

• Storage: Keep container tightly closed in a cool, dry place. Avoid exposure to light, air, and strong oxidizing agents.

• Stability: Stable under normal laboratory conditions; inert to mild acids and bases.

• Disposal: Dispose of according to local environmental and institutional regulations.

SUMMARY
N-Methylpiperazine-2,2,3,3,5,5,6,6-d₈ (CAS 917358-65-7) is a high-purity, deuterated heterocyclic amine extensively utilized in analytical chemistry, isotopic labeling, and pharmaceutical research. Its structural equivalence to N-methylpiperazine and robust deuterium enrichment make it an indispensable tool in mass spectrometry quantitation, metabolic tracing, and kinetic isotope studies. Combining stability, precision, and versatility, it supports advanced analytical applications across chemical, biological, and pharmaceutical sciences.