Nonanoic-d17-acid | CAS 130348-94-6

OVERVIEW of Nonanoic-d17-acid | CAS 130348-94-6

Nonanoic-d₁₇-acid, also known as pelargonic-d₁₇ acid, is a fully deuterated form of nonanoic acid, a nine-carbon saturated fatty acid naturally occurring in various plant oils. It has the molecular formula C₉D₁₇O₂ and a molecular weight of approximately 163.30 g/mol. In this isotopically enriched analog, all exchangeable hydrogen atoms are replaced by deuterium, allowing for precise isotopic discrimination during mass spectrometric analysis.

This compound serves as a stable isotope-labeled internal standard in lipidomics, metabolomics, and environmental chemistry. Its deuteration provides a mass shift relative to non-labeled nonanoic acid, enabling unambiguous detection and quantification in complex biological or environmental matrices.

Because its physical and chemical characteristics closely resemble those of native nonanoic acid, Nonanoic-d₁₇-acid behaves identically during extraction, separation, and derivatization processes, ensuring analytical consistency and metabolic relevance. It is a valuable analytical standard for researchers investigating medium-chain fatty acid metabolism, lipid oxidation, and volatile organic acid profiling.

CHEMICAL INFORMATION

• Name: Nonanoic-d₁₇-acid

• CAS Number: 130348-94-6

• Molecular Formula: C₉D₁₇O₂

• Molecular Weight: 175.34 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Class: Deuterated saturated fatty acid

• Solubility: Insoluble in water; soluble in most organic solvents such as chloroform, hexane, ether, and ethanol

APPLICATIONS  of  Nonanoic-d17-acid | CAS 130348-94-6

1. Mass Spectrometry and Chromatographic Analysis:
Nonanoic-d₁₇-acid is primarily used as a stable isotope-labeled internal standard in gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS) analyses. The deuterium atoms impart a distinct mass difference, allowing accurate quantification of native nonanoic acid in biological, food, or environmental samples.

2. Lipidomics and Metabolomics:
In lipidomics research, this compound is utilized for profiling medium-chain fatty acids in complex lipid extracts. It supports precise measurement of endogenous fatty acid levels and assists in identifying metabolic alterations in health and disease. Its high isotopic purity ensures consistent performance across analytical runs.

3. Environmental and Forensic Chemistry:
Deuterated nonanoic acid is an important reference standard for detecting and quantifying organic acids in environmental samples such as soils, waters, and aerosols. It helps validate extraction and quantitation procedures in environmental monitoring and forensic investigations.

4. Metabolic Pathway Tracing:
Due to its isotopic label, Nonanoic-d₁₇-acid is used as a tracer in studies of fatty acid oxidation, β-oxidation kinetics, and energy metabolism. It allows researchers to monitor fatty acid utilization and turnover in both in vitro and in vivo systems.

5. Analytical Method Development and Validation:
This compound serves as a reliable reference material for developing and validating chromatographic or spectrometric analytical methods. Its predictable behavior under analytical conditions ensures reproducibility and traceability in quantitative analyses.

6. Industrial and Biochemical Applications:
Beyond academic research, Nonanoic-d₁₇-acid is also relevant in the formulation and stability testing of products containing nonanoic acid derivatives, such as esters, lubricants, and surfactants.

ADVANTAGES  of  Nonanoic-d17-acid | CAS 130348-94-6

• High Isotopic Purity: Ensures clean and distinct mass spectral separation from non-deuterated analogs.

• Analytical Precision: Ideal for use as an internal standard in isotope dilution GC-MS and LC-MS/MS.

• Structural Fidelity: Chemically identical to non-deuterated nonanoic acid, ensuring consistent chromatographic behavior.

• Wide Applicability: Suitable for metabolomics, lipidomics, toxicology, and industrial research.

• Improved Quantification: Enables accurate normalization and correction for matrix effects during sample processing.

• Excellent Stability: Resistant to degradation and isotopic exchange under standard storage conditions.

• Method Validation Utility: Enhances reproducibility and reliability in fatty acid analytical methods.

SUMMARY
Nonanoic-d₁₇-acid (CAS 130348-94-6) is a deuterium-labeled analog of nonanoic acid that serves as a powerful analytical and research-grade reagent in lipid, metabolic, and environmental chemistry. Its 17 deuterium atoms provide a precise isotopic shift for robust quantification of native compounds through mass spectrometric techniques.

This compound enables high-fidelity tracking of fatty acid metabolism, supports lipidomics profiling, and provides superior analytical accuracy as an internal standard. Its physical properties and chemical reactivity mirror those of its unlabeled counterpart, ensuring that experimental conditions remain biologically and analytically relevant.

At ResolveMass Laboratories Inc., Nonanoic-d₁₇-acid is produced to meet exacting standards of isotopic and chemical purity. It supports advanced research in areas such as bioenergetics, metabolomics, environmental monitoring, and method validation.

By incorporating Nonanoic-d₁₇-acid into analytical workflows, researchers can enhance the precision, reproducibility, and interpretive strength of their fatty acid studies—making it an indispensable reference compound for modern mass spectrometric and biochemical investigations.

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