Octanoic-d15-acid | CAS 69974-55-6

OVERVIEW  of  Octanoic-d15-acid | CAS 69974-55-6

Octanoic-d₁₅-acid, also known as caprylic-d₁₅ acid, is a fully deuterated analog of octanoic acid, a naturally occurring medium-chain fatty acid with the formula C₈D₁₅O₂ and a molecular weight of approximately 151.27 g/mol. This compound features 15 deuterium atoms replacing all the hydrogen atoms in the aliphatic chain, providing a substantial isotopic mass difference that makes it ideal for analytical and research purposes.

Deuterated octanoic acid is widely used in lipidomics, metabolomics, and mass spectrometric quantification of fatty acids. Because it shares nearly identical chemical and physical behavior with its non-deuterated counterpart, it acts as a precise internal standard in complex sample matrices without altering chemical equilibria or extraction efficiencies.

In addition to its analytical importance, Octanoic-d₁₅-acid serves as a valuable tracer molecule in the study of fatty acid metabolism, energy production, and oxidative degradation in biological systems. It is also applied in the environmental and food industries for validating analytical methods used to detect and quantify fatty acid contaminants or natural components.

CHEMICAL INFORMATION

• Name: Octanoic-d₁₅-acid

• CAS Number: 69974-55-6

• Molecular Formula: C₈D₁₅O₂

• Molecular Weight: 151.31 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Class: Deuterated medium-chain fatty acid

• Solubility: Insoluble in water; soluble in ethanol, diethyl ether, chloroform, and other organic solvents

APPLICATIONS of Octanoic-d15-acid | CAS 69974-55-6

1. Analytical and Mass Spectrometric Applications:
Octanoic-d₁₅-acid is extensively used as an isotopically labeled internal standard for quantifying octanoic acid and related fatty acids in biological and environmental samples via GC-MS and LC-MS/MS. The 15-deuterium isotope shift provides clear mass differentiation, ensuring accurate peak identification and quantification even in complex chromatograms.

2. Lipidomics and Metabolomics Research:
In lipid metabolism studies, this compound helps in tracking the synthesis, oxidation, and degradation of medium-chain fatty acids (MCFAs). Researchers utilize Octanoic-d₁₅-acid to monitor enzymatic β-oxidation and to identify shifts in fatty acid composition under varying physiological or pathological conditions.

3. Environmental and Food Testing:
Octanoic-d₁₅-acid serves as a reference material for validating analytical protocols in detecting free fatty acids and related compounds in food products, natural extracts, and environmental pollutants. It aids in calibration of chromatographic systems and in the verification of recovery rates during sample preparation.

4. Metabolic Tracer Studies:
Because of its stable isotopic label, this compound is ideal for metabolic flux analysis and tracer studies investigating fatty acid utilization in cells, tissues, or whole organisms. It provides non-radioactive, precise tracing capability to map biochemical pathways involving medium-chain fatty acid oxidation.

5. Pharmaceutical and Biomedical Research:
Deuterated fatty acids like Octanoic-d₁₅-acid are explored for their potential role in modulating oxidative stress and cellular lipid balance. In biomedical studies, it aids in characterizing mitochondrial efficiency and understanding disorders of lipid metabolism.

6. Method Development and Validation:
Analytical laboratories employ Octanoic-d₁₅-acid to standardize and validate chromatographic and spectrometric techniques, ensuring reliable quantification of native fatty acids across various sample types.

ADVANTAGES  of  Octanoic-d15-acid | CAS 69974-55-6

• High Isotopic Enrichment: Provides excellent mass separation for isotope dilution assays.

• Superior Analytical Accuracy: Functions as a stable and precise internal standard for octanoic acid quantification.

• Structural Equivalence: Mirrors the physicochemical behavior of non-deuterated octanoic acid, enabling consistent analytical performance.

• Enhanced Stability: Exhibits superior chemical and isotopic stability during storage and analysis.

• Non-Radioactive Labeling: Safe and convenient alternative to radiolabeled tracers in metabolic research.

• Wide Application Spectrum: Suitable for use in biochemical, environmental, and industrial analysis workflows.

• Improved Reproducibility: Minimizes variability and enhances the reliability of quantitative fatty acid analysis.

SUMMARY
Octanoic-d₁₅-acid (CAS 69974-55-6) is a fully deuterated derivative of octanoic acid designed for advanced analytical, biochemical, and environmental research. It offers exceptional isotopic purity and serves as a robust internal standard in mass spectrometry-based fatty acid quantification.

This compound’s close chemical resemblance to native octanoic acid allows it to function seamlessly in metabolic studies, lipidomics, and method development applications. By providing accurate, stable, and reproducible data, it supports critical investigations into fatty acid metabolism, oxidative stress, and lipid biochemistry.

At ResolveMass Laboratories Inc., Octanoic-d₁₅-acid is produced under stringent isotopic and chemical purity controls, ensuring premium analytical quality. Researchers and analysts can rely on this deuterated fatty acid for high-precision isotope dilution assays, method calibration, and metabolic tracing in both biological and environmental systems.

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