Parathion-d10 (diethyl-d10) | CAS 350820-04-1

OVERVIEW
Parathion-d₁₀ (diethyl-d₁₀) is the fully deuterated isotopologue of parathion, an organophosphate pesticide historically used for controlling a wide range of agricultural pests. In this isotopically labeled compound, all ten hydrogen atoms of the two ethyl groups in the parathion molecule are replaced by deuterium, resulting in a molecular weight increase of +10 Da while maintaining the same chemical reactivity and physical properties as native parathion.

Parathion-d₁₀ is primarily utilized as a stable isotope-labeled internal standard in analytical chemistry, particularly in gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS) analyses. It provides highly accurate quantification of parathion residues in environmental samples, food matrices, and biological fluids by compensating for extraction losses and matrix interferences.

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CHEMICAL INFORMATION

• Name: Parathion-d₁₀

• Molecular Formula: C₁₀D₁₀NO₅PS

• Molecular Weight: 301.210 g/mol

• CAS Number: 350820-04-1

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated organophosphate pesticide

• Stability: Stable under normal storage conditions; decomposes in strong acids or bases and upon exposure to heat or light

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APPLICATIONS  of  Parathion-d10 (diethyl-d10) | CAS 350820-04-1

• Analytical Standard for Pesticide Residue Analysis:
  Parathion-d₁₀ serves as a deuterated internal standard in the quantitative analysis of parathion residues in food products, soil, air, and water samples. The deuterium labeling provides a distinct isotopic mass difference that allows accurate differentiation during GC-MS or LC-MS detection.

• Environmental Monitoring:
  Used by environmental laboratories to detect and quantify organophosphate pesticides in contaminated environments, ensuring compliance with regulatory safety limits for pesticide residues in ecosystems.

• Toxicological Research:
  Applied as a tracer in toxicokinetic and metabolic studies to investigate the absorption, distribution, metabolism, and excretion (ADME) of parathion and related compounds. The deuterium label enables precise tracking of the compound in biological systems.

• Quality Control in Analytical Methods:
  Functions as a calibration and performance standard in pesticide screening assays, supporting the development and validation of sensitive analytical methods for organophosphate detection.

• Stable Isotope Tracing:
  Employed in mechanistic studies of organophosphate hydrolysis, oxidation, and environmental degradation, providing insights into parathion’s persistence and transformation pathways.

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ADVANTAGES  of  Parathion-d10 (diethyl-d10) | CAS 350820-04-1

• Fully deuterated (+10 Da) for precise isotopic resolution in mass spectrometry

• Chemically identical to native parathion for consistent analytical behavior

• High isotopic enrichment (≥98 atom % D) ensures superior reliability

• Non-radioactive, safe, and stable for long-term analytical use

• Enables accurate quantification at ultra-trace levels in complex matrices

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HANDLING

• Hazards: Parathion and its isotopic forms are highly toxic organophosphate compounds that act as potent cholinesterase inhibitors. Even minimal exposure can cause severe poisoning; handle only in well-ventilated fume hoods by trained personnel.

• Precautions: Use appropriate PPE including gloves, goggles, and protective clothing. Avoid inhalation, ingestion, and skin contact. Do not use near sources of ignition or heat.

• Storage: Keep tightly sealed in amber glass containers under inert conditions (e.g., nitrogen). Store at 2–8 °C, protected from light and moisture.

• Disposal: Dispose of parathion-d₁₀ and contaminated materials in accordance with hazardous waste regulations for organophosphates.

Safety Note: Although deuterated, parathion-d₁₀ retains the acute toxicity and neurotoxic mechanism of non-deuterated parathion. It should be handled with extreme care under institutional safety protocols.

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QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.05 %

• Analytical Verification: Characterized by ¹H NMR, ²H NMR, IR spectroscopy, and high-resolution mass spectrometry (HRMS)

• COA Provided: Certificate of Analysis available for each lot confirming isotopic enrichment and chemical purity

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SUMMARY
Parathion-d₁₀ (diethyl-d₁₀) (CAS 350820-04-1) is a high-purity, stable isotope-labeled analog of parathion, primarily used as an internal standard for quantitative pesticide residue analysis. Its high isotopic enrichment and stability make it an indispensable reference material in environmental monitoring, toxicological studies, and analytical method validation. Despite its analytical importance, it retains the extreme toxicity of parathion and requires careful handling under controlled laboratory conditions.

 

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