Phosmet-d6 (dimethyl-d6) | CAS 2083623-41-8

OVERVIEW  of  Phosmet-d6 (dimethyl-d6) | CAS 2083623-41-8
Phosmet-d₆ (dimethyl-d₆) is a stable isotopically labeled analog of phosmet, a broad-spectrum organophosphate insecticide widely used in agricultural pest control. In this deuterated derivative, the two methyl groups in the phosphorodithioate moiety are replaced with deuterium atoms, resulting in a total of six deuterium substitutions. This isotopic modification produces a molecular weight increase of +6 Da while retaining identical physicochemical and biological properties to native phosmet.

Phosmet-d₆ is primarily employed as an internal standard in mass spectrometric (MS) and chromatographic (GC-MS and LC-MS/MS) analyses for the quantification of phosmet residues in environmental, food, and biological samples. It is also used in metabolism, degradation pathway studies, and toxicological investigations to trace the fate and transformation of organophosphates under controlled laboratory or environmental conditions.

CHEMICAL INFORMATION

•  Name: Phosmet-d₆

• Molecular Formula: C₁₁H₆D₆NO₄PS₂

• Molecular Weight: 333.36 g/mol

• CAS Number: 2083623-41-8

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Organophosphate insecticide; stable isotope-labeled analog

• Stability: Stable under normal storage conditions; decomposes under strongly acidic or alkaline environment.

APPLICATIONS  of  Phosmet-d6 (dimethyl-d6) | CAS 2083623-41-8

• Mass Spectrometry and Chromatographic Standards:
  Phosmet-d₆ serves as a deuterated internal standard in LC-MS/MS and GC-MS assays, allowing precise quantification of phosmet residues by providing a clear isotopic mass distinction (+6 Da) from the native compound.

• Environmental and Agricultural Research:
  Used as a stable isotope tracer to monitor degradation, adsorption, and metabolic transformation of phosmet in soil, plants, and aquatic systems.

• Toxicological and Pharmacokinetic Studies:
  Facilitates detailed examination of absorption, distribution, metabolism, and excretion (ADME) pathways of organophosphate insecticides in biological organisms.

• Method Validation and Quality Assurance:
  Ideal for instrument calibration, method validation, and quality control in pesticide residue laboratories. The isotopic labeling ensures high analytical reproducibility and sensitivity.

ADVANTAGES  of  Phosmet-d6 (dimethyl-d6) | CAS 2083623-41-8

• High isotopic enrichment (≥ 98 atom % D) ensures excellent spectral differentiation in MS-based quantification.

• Chemically equivalent to native phosmet, maintaining identical chromatographic and reactivity profiles.

• Non-radioactive, stable, and environmentally safe isotope tracer.

• Provides accurate and reproducible data in isotope dilution and trace residue analysis.

• Suitable for long-term storage and multi-matrix analytical use.

HANDLING, STORAGE & SAFETY

• Hazards: As an organophosphate analog, phosmet-d₆ is toxic and may inhibit cholinesterase activity upon exposure. It should be treated with the same caution as non-deuterated phosmet.

• Precautions: Handle only in a fume hood or controlled environment. Use appropriate PPE including gloves, goggles, and lab coat. Avoid inhalation, ingestion, and skin contact.

• Storage: Keep in tightly sealed amber glass containers at 2–8 °C, under an inert atmosphere such as nitrogen or argon.

• Disposal: Dispose of as hazardous chemical waste according to local environmental regulations for organophosphates.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Water Content: ≤ 0.5 %

• Analytical Verification: Confirmed by GC-MS, LC-MS, ¹H NMR (absence of proton peaks), and ²H NMR (deuterium incorporation verification).

• Physical State: Light yellow to off-white solid

• Documentation: Certificate of Analysis (CoA) provided with isotopic and purity data

SUMMARY
Phosmet-d₆ (dimethyl-d₆) | CAS 2083623-41-8 is a deuterium-labeled analog of phosmet designed for high-precision analytical and environmental applications. Its isotopic substitution enables accurate residue quantification, isotopic tracing, and method calibration in pesticide residue analysis. With excellent chemical stability, high isotopic enrichment, and analytical reliability, Phosmet-d₆ is an indispensable standard for laboratories involved in environmental monitoring, agrochemical research, and toxicological assessment of organophosphate insecticides.