Piperazine-d10 | CAS 362049-61-4

OVERVIEW  of  Piperazine-d10 | CAS 362049-61-4

Piperazine-d10 (CAS 362049-61-4) is a fully deuterated analogue of piperazine, in which all hydrogen atoms on the two –CH₂– groups are replaced with deuterium atoms, providing a total of ten deuterium substitutions. This isotopically labeled compound is widely utilized in mass spectrometry (MS), NMR spectroscopy, and pharmaceutical research as an internal standard, reference compound, or isotopic tracer. The full deuteration enhances its utility for metabolic studies, kinetic isotope effect analysis, and drug metabolism investigations involving piperazine-containing molecules.

CHEMICAL INFORMATION

• Name: Piperazine-d10

• Molecular Formula: C₄D₁₀N₂

• Molecular Weight: 96.20 g/mol

• CAS Number: 362049-61-4

• Isotopic Labeling: Ten deuterium atoms (fully deuterated structure)

• Chemical Class: Deuterated heterocyclic amine

• Stability: Stable under normal storage conditions; hygroscopic

APPLICATIONS  of  Piperazine-d10 | CAS 362049-61-4

• Mass Spectrometry (MS):
  Used as a stable isotopic internal standard for quantifying piperazine derivatives and related pharmaceuticals.

• NMR Spectroscopy:
  Suitable for use as a reference compound or deuterium-labeled solvent component, providing background suppression in ¹H NMR spectra.

• Pharmaceutical and Medicinal Chemistry:
  Acts as an isotopically labeled building block for synthesizing deuterated analogues of drug candidates containing piperazine moieties (e.g., antihistamines, antipsychotics).

• Metabolic and Pharmacokinetic Studies:
  Enables isotopic tracing of metabolic pathways, drug metabolism, and clearance mechanisms.

• Analytical and Calibration Standards:
  Used for developing quantitative analytical methods requiring isotope-labeled standards with high deuterium enrichment.

ADVANTAGES  of  Piperazine-d10 | CAS 362049-61-4

• ≥ 98 atom % D isotopic purity ensures high analytical precision.

• Chemically identical to non-deuterated piperazine, ensuring comparable reactivity and behavior.

• Excellent solubility in aqueous and polar organic media.

• Ideal for both qualitative and quantitative analytical methods.

• Non-radioactive and safe for laboratory use.

HANDLING, STORAGE & SAFETY

• Handling: Use in a dry environment; avoid exposure to moisture and air.

• Storage: Keep in tightly closed container at 2–8 °C.

• Safety: Generally low hazard; may cause slight skin or eye irritation. Use gloves and eye protection.

• Disposal: Dispose of in accordance with local environmental regulations.

QUALITY & SPECIFICATION

• Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Analytical Characterization: Verified by ¹H NMR (proton signal absence), ²H NMR, IR, and GC–MS

• Documentation: Certificate of Analysis (CoA) provided upon request

SUMMARY
Piperazine-d10 (CAS 362049-61-4) is a highly deuterated, stable isotopic compound used in analytical, pharmaceutical, and chemical research. Its complete deuterium substitution provides a reliable internal standard for MS and NMR applications, while its structural similarity to native piperazine ensures accurate comparison in drug metabolism and kinetic studies. Piperazine-d10 is an indispensable tool for quantitative isotopic labeling and advanced analytical chemistry.