Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) | PLGA: mPEG: PLGA (Mw 5000: 4000:5000 | CAS 952 111-10-3

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) | PLGA: mPEG: PLGA (Mw 5000: 4000:5000 | CAS 952 111-10-3

 

OVERVIEW

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide) | PLGA: mPEG: PLGA (Mw 5000: 4000:5000 | CAS 952 111-10-3 supplied by ResolveMass Laboratories Inc. is a high-performance amphiphilic triblock copolymer engineered for advanced drug-delivery and biomedical formulations. This specific grade—PLGA : mPEG : PLGA (25,000 : 4,000 : 25,000), total nominal molecular weight ≈ 54 kDa, CAS 952-111-10-3—offers a balance of hydrophilicity and hydrophobicity optimized for controlled release, micelle formation, tissue engineering, and injectable depot systems. Its structure, featuring hydrophobic PLGA end blocks flanking a hydrophilic PEG core, enables exceptional self-assembly, predictable degradation, and formulation versatility across a wide range of APIs.

ResolveMass provides this polymer with strict analytical characterization, batch consistency, and technical support to help formulation scientists develop high-performance prototypes, preclinical systems, and translational delivery technologies.

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CHEMICAL INFORMATION

• Chemical Name: Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

• Abbreviation: PLGA-PEG-PLGA (triblock)

• Block Molecular Weights: PLGA 5,000 – PEG 4,000 – PLGA 5,000

• Typical Total Mw: ~54,000 Da

• CAS Number: 952-111-10-3

• Polymer Type: Amphiphilic, biodegradable triblock copolymer

• PLGA Composition: Lactic:glycolic ratio available upon request; custom ratios support tailored degradation rates.

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KEY FEATURES

• Amphiphilic triblock architecture for micelle formation and enhanced drug solubilization

• Controlled and tunable degradation driven by PLGA block structure

• PEG mid-block offers hydrophilicity, steric shielding, and reduced protein adsorption

• Biocompatible and biodegradable into lactic and glycolic acid

• Suitable for hydrophobic APIs, peptides, proteins, and imaging agents

• Consistent molecular weight distribution verified by GPC/SEC

• High-purity material with low residual solvent content

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APPLICATIONS  

This PLGA-PEG-PLGA triblock is used widely in research and development of:

• Sustained-release injectable depots: Forms in situ gels or controlled-release matrices after solvent evaporation or aqueous self-assembly.

• Nanoparticles and micelles: Core–shell structures capture hydrophobic drugs and protect sensitive biologics.

• Thermoresponsive gels: Some formulations exhibit sol–gel transitions near physiological temperatures, ideal for localized delivery.

• Protein and peptide delivery: PEG middle block minimizes aggregation and immunogenicity while PLGA controls release rates.

• Tissue engineering hydrogels: Supports cell encapsulation, regenerative scaffolds, and controlled growth factor release.

• Surface modification: PEG provides functional handles for ligand attachment, targeting, or stealth coating.

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FORMULATION BENEFITS

• Versatile drug loading: Compatible with small molecules, peptides, proteins, and imaging compounds.

• Predictable release kinetics: Block lengths and PLGA composition modulate degradation from weeks to months.

• Reduced burst release: Hydrophobic PLGA ends create a stable core that moderates initial drug diffusion.

• Improved stability: PEG corona reduces opsonization and enhances blood circulation for nanoparticulate systems.

• Aqueous processing compatibility: Enables thermogelling or micelle-based formulations without harsh processing conditions.

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ANALYTICAL SPECIFICATIONS

ResolveMass provides full analytical documentation including:

• GPC/SEC: Molecular weight and PDI

• ¹H NMR: Block verification and PEG content

• FTIR: Functional group confirmation

• Residual solvent and monomer data: GC/MS or HPLC upon request

• Thermal analysis (DSC/TGA): Supporting data for formulation stability studies

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REGULATORY & QUALITY SUPPORT

ResolveMass Laboratories Inc. supplies research-grade PLGA-PEG-PLGA with full documentation for analytical characterization, reproducibility, and traceability. Custom molecular weights, PLGA ratios, end-group types, and tailored material specifications are available to support advanced development programs, preclinical studies, and translational R&D.

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