Propionic-2,2-d2 Acid | CAS 19136-91-5

OVERVIEW  of  Propionic-2,2-d2 Acid | CAS 19136-91-5

Propionic-2,2-d₂ acid (CAS 19136-91-5) is a deuterium-labeled analog of propionic acid, a three-carbon short-chain fatty acid (SCFA) widely found in biological and environmental systems. In this compound, two hydrogen atoms at the α-carbon (C2) are replaced with deuterium, producing a distinct isotopic signature valuable for mass spectrometry (MS) and nuclear magnetic resonance (NMR) applications. It is commonly utilized in metabolomics, stable isotope tracer studies, and quantitative analysis of volatile fatty acids (VFAs).

CHEMICAL INFORMATION

• Name: Propionic-2,2-d₂ acid

• Molecular Formula: C₃H₄D₂O₂

• Molecular Weight: 76.09 g/mol

• CAS Number: 19136-91-5

• Isotopic Enrichment: ≥ 98 atom % D (at C2 position)

• Chemical Class: Deuterated carboxylic acid / SCFA analog

• Solubility: Miscible with water, alcohols, and most polar organic solvents

APPLICATIONS  of  Propionic-2,2-d2 Acid | CAS 19136-91-5

• Stable Isotope Internal Standard:
  Serves as a quantitative internal standard in GC-MS or LC-MS analyses for determining propionic acid concentrations in biological samples, foods, and fermentation media.

• Metabolic Tracing Studies:
  Widely used in biochemical pathway analysis to investigate fatty acid metabolism, microbial fermentation, and gut microbiota SCFA production.

• Isotope Dilution Mass Spectrometry (IDMS):
  Used as a reference compound for calibration and quantification of volatile organic acids, enhancing accuracy and reproducibility in analytical assays.

• NMR Applications:
  Applied in ¹H/²H NMR experiments to study isotopic effects and molecular interactions in deuterated environments.

• Environmental & Industrial Chemistry:
  Utilized in biodegradation research to track carbon flow and understand environmental transformation of small carboxylic acids.

ADVANTAGES  of  Propionic-2,2-d2 Acid | CAS 19136-91-5

• High deuterium enrichment ensures precise mass distinction from unlabeled analogs.

• Ideal for quantitative and kinetic isotope effect studies.

• Chemically identical to native propionic acid, maintaining similar reactivity and solubility.

• Enhances accuracy and traceability in complex matrix analyses.

HANDLING AND SAFETY

• Handling Precautions: Avoid contact with skin, eyes, and mucous membranes; use under adequate ventilation.

• Protective Equipment: Laboratory gloves, safety glasses, and protective clothing recommended.

• Storage: Keep container tightly closed in a cool, dry, and dark location.

• Stability: Stable under normal laboratory conditions; avoid prolonged exposure to air and moisture.

• Disposal: Dispose of according to institutional and local environmental regulations.

SUMMARY
Propionic-2,2-d₂ acid (CAS 19136-91-5) is a deuterium-enriched short-chain fatty acid specifically designed for quantitative analytical chemistry and metabolic research. Its stability, isotopic precision, and compatibility with modern spectroscopic techniques make it a valuable reagent for metabolomics, environmental tracing, and analytical standardization in both academic and industrial laboratories.