Terephthalic-2,3,5,6-d4 Acid | CAS 60088-54-2

OVERVIEW  of  Terephthalic-2,3,5,6-d4 Acid | CAS 60088-54-2

Terephthalic-2,3,5,6-d₄ Acid is a deuterium-labeled aromatic dicarboxylic acid commonly used as a reference material, internal standard, and stable isotopic tracer in analytical chemistry, polymer science, and environmental studies. As the deuterated analogue of terephthalic acid, the compound contains four deuterium atoms located on the benzene ring, providing a clear and predictable mass shift without altering the underlying chemical behavior of the native molecule.
Terephthalic acid and its derivatives play a major role in manufacturing polyesters, PET resins, textiles, films, coatings, and industrial plastics. Because of this widespread usage, accurate quantification and tracking of terephthalic acid—especially at trace levels—is essential for research, quality control, and environmental monitoring. Terephthalic-d₄ Acid provides a stable and highly reliable analytical standard for laboratories looking to improve precision and accuracy.

CHEMICAL INFORMATION

• Name: Terephthalic-2,3,5,6-d₄ Acid

• CAS Number: 60088-54-2

• Molecular Formula: C₈H₂D₄O₄

• Molecular Weight: ~170.16 g/mol

• Isotopic Enrichment: Typically ≥98% D

• Chemical Class: Aromatic dicarboxylic acid (para-substituted)

• Stability: Highly stable under standard storage; resistant to isotopic exchange under neutral conditions

APPLICATIONS  of  Terephthalic-2,3,5,6-d4 Acid | CAS 60088-54-2
Terephthalic-2,3,5,6-d₄ Acid has broad utility across analytical and industrial fields due to its reliable isotopic labeling and structural integrity:

• Internal Standard for LC-MS and GC-MS:
  Provides distinct mass separation for trace-level quantification of terephthalic acid in complex matrices such as polymer extracts, environmental samples, and biological fluids.

• Polymer and PET Industry Analysis:
  Used to evaluate degradation pathways of PET materials, migration of monomers, and product purity in polyester manufacturing.

• Quality Control and Method Validation:
  Helps determine extraction recovery, calibration accuracy, and reproducibility in high-precision analytical workflows.

• Environmental Monitoring:
  Supports analyses of industrial wastewater, landfill leachates, soil samples, and aquatic environments where terephthalic acid or PET breakdown products may accumulate.

• Metabolic and Degradation Studies:
  Assists in tracking microbial degradation pathways of terephthalic acid and related aromatic compounds.

• Isotope Dilution Mass Spectrometry (IDMS):
  Enables absolute quantification with superior analytical robustness.

• Kinetic and Mechanistic Studies:
  Deuterium labeling allows investigation of reaction mechanisms, isotope effects, and catalytic processes involving aromatic dicarboxylates.

ADVANTAGES  of  Terephthalic-2,3,5,6-d4 Acid | CAS 60088-54-2

• Clear Mass Shift for Reliable Identification:
  Deuteration at four positions ensures strong and easily identifiable MS signals.

• Chemically Equivalent to Native Terephthalic Acid:
  Ensures consistent behavior during extraction, chromatography, and ionization.

• Excellent Stability:
  Resistant to oxidation, hydrolysis, and isotopic scrambling, ensuring long-term usability.

• Ideal for Precision Analytical Workflows:
  Enhances quantification accuracy, especially in trace-level analyses or heavily interfered matrices.

• Compatible with a Broad Range of Techniques:
  Suitable for LC-MS, GC-MS (after derivatization), NMR, IR spectroscopy, and polymer-analytical platforms.

• Supports Regulatory Testing:
  Highly relevant for industries requiring stringent quality control, such as PET packaging, food-contact materials, and synthetic fibers.

SUMMARY
Terephthalic-2,3,5,6-d₄ Acid is a highly valuable isotopically labeled aromatic dicarboxylic acid designed for advanced analytical, environmental, and polymer-related research. Its four deuterium atoms create a stable isotopic signature while preserving the exact chemical behavior of native terephthalic acid, making it an ideal internal standard and reference material for mass spectrometry-based quantification. Widely used in PET manufacturing studies, environmental monitoring, material degradation research, and method development, this compound provides high accuracy, reproducibility, and confidence in analytical results. For laboratories seeking to enhance trace detection, method robustness, and scientific reliability, Terephthalic-d₄ Acid is an indispensable tool.

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