tert-butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate | CAS 1323952-12-0

OVERVIEW
tert-butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate | CAS 1323952-12-0, is a high-purity chemical intermediate widely utilized in medicinal chemistry, pharmaceutical research, and drug discovery applications. This compound features a pyrimidine core functionalized with a chlorinated substituent at the 5-position, linked to a piperazine moiety protected by a tert-butyl carbamate (Boc) group. Its unique structural attributes make it an important building block for synthesizing bioactive heterocyclic compounds, particularly in the development of kinase inhibitors, CNS-active agents, and other therapeutic candidates.

ResolveMass Laboratories Inc. supplies this compound with stringent quality controls, ensuring batch-to-batch consistency, high purity, and compatibility with both laboratory-scale and larger-scale synthetic operations. Our dedicated analytical teams validate each shipment using robust techniques, including NMR, HPLC, LC-MS, and IR spectroscopy, to confirm chemical identity, purity, and structural integrity.

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CHEMICAL INFORMATION

• IUPAC Name: tert-butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate

• CAS Number: 1323952-12-0

• Molecular Formula: C13H18ClN5O2

• Molecular Weight: 298.77 g/mol

This chemical exhibits high thermal and chemical stability, making it suitable for a variety of synthetic transformations, including nucleophilic substitution reactions, cross-coupling reactions, and Boc deprotection strategies.

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APPLICATIONS of tert-butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate | CAS 1323952-12-0

1. Pharmaceutical and Medicinal Chemistry Research
   tert-Butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate is a critical intermediate in the synthesis of bioactive heterocyclic compounds. Its chloropyrimidine moiety can undergo selective substitution, facilitating the design and preparation of kinase inhibitors, antiviral agents, and CNS-targeted therapeutics.

2. Drug Discovery and Lead Optimization
   In medicinal chemistry programs, this compound allows chemists to explore SAR (Structure-Activity Relationship) by introducing diverse substituents at the pyrimidine ring. Its Boc-protected piperazine ensures selective reactions while preventing undesired side reactions during multi-step syntheses.

3. Custom Synthesis and Intermediate Development
   Due to its well-defined functional groups, it serves as a versatile scaffold for multi-step organic syntheses. Researchers can utilize it in fragment-based drug design or combinatorial chemistry to develop novel chemical libraries for screening programs.

4. Analytical and Method Development
   The compound’s stable chemical structure makes it an ideal reference standard in analytical method development, including HPLC method validation and LC-MS profiling of synthetic intermediates.

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WHY CHOOSE RESOLVEMASS LABORATORIES

ResolveMass Laboratories Inc. provides tert-butyl 4-(5-chloropyrimidin-2-yl)piperazine-1-carboxylate in research-grade quality with a focus on regulatory compliance, reproducibility, and traceability. Each batch is accompanied by a comprehensive certificate of analysis (CoA) and analytical validation reports, ensuring that researchers and pharmaceutical developers can rely on the integrity of the compound for their critical projects.

• High Purity & Consistency: Each batch is rigorously tested for ≥98% purity.

• Comprehensive Analytical Support: NMR, HPLC, LC-MS, and elemental analysis data are provided.

• Research & Development Focus: Ideal for medicinal chemistry, drug discovery, and custom synthesis projects.

• Scalable Supply: Available for milligram to multi-gram quantities, supporting both early-stage research and larger preclinical studies.

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SAFETY AND HANDLING

This compound should be handled in accordance with standard laboratory safety protocols for chlorinated heterocyclic chemicals. Personal protective equipment (PPE) such as gloves, safety goggles, and lab coats is recommended. Work should be performed in a well-ventilated environment or fume hood. Dispose of chemical waste according to local regulations.