tert-butyl (9-trityl-9H-purin-6-yl)carbamate | CAS 1229622-72-3

PRODUCT OVERVIEW

tert-butyl (9-trityl-9H-purin-6-yl)carbamate | CAS 1229622-72-3 is a specialized purine-based organic intermediate widely utilized in advanced chemical research, medicinal chemistry programs, and multi-step synthetic workflows. Identified by CAS Number 1229622-72-3, this compound combines a protected purine nucleus with strategically selected functional groups that enable controlled downstream transformations. Its structural design makes it particularly valuable for researchers developing novel heterocyclic frameworks and purine-derived small molecules.

At ResolveMass Laboratories Inc., this compound is supplied as a research-grade material suitable for demanding laboratory environments where consistency, chemical integrity, and traceability are essential.

CHEMICAL IDENTITY

• Chemical Name: tert-Butyl (9-trityl-9H-purin-6-yl)carbamate

• CAS Number: 1229622-72-3

• Molecular Formula: C₂₉H₂₇N₅O₂

• Molecular Weight: 477.57 g/mol

• Chemical Class: Purine derivative / Carbamate-protected heterocycle

This compound contains a purine core substituted at the N-9 position with a trityl protecting group and at the C-6 position with a tert-butyl carbamate moiety, offering excellent compatibility with orthogonal protection strategies commonly used in organic synthesis.

STRUCTURAL CHARACTERISTICS & DESIGN RATIONALE

The purine scaffold is one of the most biologically relevant heterocyclic systems in chemistry, serving as a foundation for nucleobases, cofactors, and numerous therapeutic agents. In tert-butyl (9-trityl-9H-purin-6-yl)carbamate | CAS 1229622-72-3, this scaffold is intentionally modified to enhance synthetic control and flexibility.

The trityl group provides robust protection of the N-9 nitrogen, preventing unwanted side reactions during coupling, substitution, or functionalization steps. Its bulky aromatic nature also improves handling characteristics and stability during multi-step synthesis.

The tert-butyl carbamate (Boc) group is a widely accepted amine-protecting group, valued for its acid-labile properties. This allows selective deprotection under mild conditions without disturbing other functional groups within complex molecular assemblies.

Together, these features make this compound an excellent intermediate for precision-driven synthesis.

APPLICATIONS IN RESEARCH & DEVELOPMENT

Medicinal Chemistry

This compound is frequently employed in the design and synthesis of purine analogs, which are central to many drug discovery programs. Purine derivatives are known to interact with kinases, receptors, and nucleic acid-related pathways, making them attractive scaffolds for lead optimization and structure-activity relationship studies.

Organic & Heterocyclic Synthesis

The protected nature of this molecule allows chemists to introduce additional substituents at defined positions with high selectivity. It is particularly useful in multi-step synthetic routes, where maintaining functional group integrity is critical to overall yield and reproducibility.

Custom Molecule Development

Due to its modular structure, tert-butyl (9-trityl-9H-purin-6-yl)carbamate serves as a reliable starting point for creating custom heterocycles, nucleobase mimetics, and advanced intermediates tailored to specific research objectives.

SAFETY & LABORATORY USE

tert-Butyl (9-trityl-9H-purin-6-yl)carbamate is intended for research use only. It is not approved for human or veterinary applications.

Standard laboratory safety procedures should be followed at all times, including:

• Use of appropriate personal protective equipment (PPE)

• Handling in a well-ventilated area or fume hood

• Avoidance of direct contact, inhalation, or ingestion

All disposal should be carried out in accordance with institutional guidelines and regulatory requirements.

QUALITY COMMITMENT FROM RESOLVEMASS LABORATORIES INC.

ResolveMass Laboratories Inc. is committed to supplying high-quality, well-characterized chemical building blocks that support innovation in drug discovery and advanced chemical research. Each batch of tert-butyl (9-trityl-9H-purin-6-yl)carbamate | CAS 1229622-72-3 is produced and quality-checked to meet rigorous research standards, with documentation available to support regulatory and internal review needs.

Our team works closely with research organizations, CROs, and pharmaceutical scientists to ensure reliable supply, technical support, and consistency across projects.