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Isotopic Labeling Services for Drug Discovery
Pharmaceutical companies, biotech researchers, and CRO teams rely on Isotopic Labeling Services for Drug Discovery to accelerate mechanistic studies, improve ADME profiling, optimize lead candidates, and enhance structural elucidation. At ResolveMass Laboratories Inc., we deliver precision-engineered labeled compounds that support early-stage drug development through preclinical research and beyond.
As a specialized analytical and synthesis laboratory, our team has supported drug development programs for small molecules, peptide-based drugs, and targeted therapeutics. Every project is executed under controlled lab environments with rigorous documentation and reproducibility, allowing seamless regulatory submission downstream. For more advanced synthetic options, researchers can explore our custom synthesis services to complement isotopic labeling workflows.
Why Isotopic Labeling Matters in Modern Drug Discovery
Isotopic labeling enables accurate tracking of molecular pathways throughout pharmacokinetic, metabolic, and mechanistic studies. With stable isotopes such as ¹³C, ²H, and ¹⁵N, researchers can obtain quantitative insights without introducing radiation, allowing safe and compliant experimentation.
Key applications include:
- Metabolic reaction mechanism determination
- Target engagement studies
- Biodistribution & ADME profiling
- Lead optimization
- Quantitative mass spectrometry assays
- Bioanalytical method validation
- Preclinical PK/PD research
Our Isotopic Labeling Capabilities
ResolveMass Laboratories Inc. provides custom stable isotope synthesis using a chemistry-first design approach. Our platform supports labeled standards for both research and regulated environments. Explore the details of our HRMS analysis services to see how labeled compounds can improve structural
| Category | Capabilities |
|---|---|
| Isotopes | ¹³C, ²H (D), ¹⁵N, ¹⁸O |
| Compound Types | Small molecules, peptides, standards |
| Methods | Chemical synthesis, enzymatic labeling, exchange |
| Output | mg to multi-gram scale |
| Purity | Up to 99.9% isotopic purity |
| Documentation | Full QC, CoA, NMR + LC-MS data |
| Compliance | GLP support optional |
Industries and Teams We Support
- Pharmaceutical R&D
- Biotech drug developers
- CRO/CDMO partners
- Academic drug discovery labs
- Government pharmacology institutes
Many of our clients also leverage impurity profiling using LC-MS alongside isotopic labeling to gain deeper insights into drug metabolites and potential degradation products.
Quality, Documentation & Regulatory Alignment
Every synthesized labeled compound is verified using high-resolution mass spectrometry, NMR, and chromatographic purity testing. Data packages include Certificates of Analysis (CoA) and complete traceability documentation to support IND-enabling studies.
Example Project Use-Cases
✔ Deuterated drug analogs for metabolic stability studies
✔ ¹³C-labeled standards for LC-MS quantitation in ADME assays
✔ Peptide labeling for target binding research
✔ Reference materials for bioanalytical method validation
For a complete range of advanced synthesis and isotopic options, see our custom synthesis for drug discovery page to discuss your project with our experts.
Project Workflow
- Project design consultation
- Synthetic route planning
- Proof-of-concept bench synthesis
- Scale-up and purification
- QC testing & characterization
- Packaging, shipping, and documentation
Why Leading R&D Teams Trust ResolveMass Laboratories Inc.
With extensive experience supporting early-stage research programs, our scientists collaborate directly with R&D leaders to reduce uncertainty, accelerate timelines, and ensure reproducibility. Our lab maintains controlled environments, validated instrumentation, and full confidentiality on IP-sensitive projects. Many teams also combine our services with liquid chromatography-mass spectrometry (LC-MS) analysis to enhance data reliability and throughput.
Request a Custom Quote
Whether you require a labeled reference standard or full series synthesis, our team can provide rapid feasibility assessments and transparent proposal timelines. Request a consultation today to see how ResolveMass can accelerate your drug discovery program.
Frequently Asked Questions
Isotopic labeling involves substituting atoms in a molecule with their heavier isotope counterparts (like ¹³C or ²H) to trace biochemical behavior without altering chemical function. In drug discovery, this helps researchers accurately follow how compounds are absorbed, metabolized, and distributed in biological systems, enhancing insight into ADME properties.
Stable isotopes like carbon-13 (¹³C), deuterium (²H), and nitrogen-15 (¹⁵N) are most frequently used because they are non-radioactive, safe for laboratory use, and provide clear analytical signals. Radioactive isotopes such as ¹⁴C or ¹¹C are occasionally used in specialized pharmacokinetic or imaging studies.
Isotopic labels like ¹³C and ¹⁵N are essential for enhancing NMR signal clarity, especially in protein structure and dynamics studies. Labeled samples improve the resolution of spectral data, enabling identification of ligand binding and conformational changes.
Conclusion
ResolveMass Laboratories Inc. delivers reliable Isotopic Labeling Services for Drug Discovery that accelerate mechanistic insight, improve assay sensitivity, and support modern therapeutic innovation. Our collaboration-focused approach enables research teams to design better drugs with greater speed and confidence.
Reference
- Iglesias, J., Sleno, L., & Volmer, D. A. (2012). Isotopic labeling of metabolites in drug discovery applications. Current Drug Metabolism, 13(9), 1213–1225. https://doi.org/10.2174/138920012803341357
- Bragg, R. A., Bergare, J., Artelsmair, M., Kerr, W. J., Skrydstrup, T., & Elmore, C. S. (2025). Advancing isotope labeling technologies at AstraZeneca through academic-industrial collaboration. ACS Medicinal Chemistry Letters, 16(7), 1221–1225. https://doi.org/10.1021/acsmedchemlett.5c00338