PCL-PEG-PCL
(Poly(ε-caprolactone)-block-poly(ethylene glycol)-block-poly(ε-caprolactone))
PCL-PEG-PCL Triblock Copolymer – Biodegradable Thermo-Responsive Polymers for Advanced Drug Delivery
ResolveMass Laboratories Inc. offers high-purity PCL-PEG-PCL triblock copolymers, designed for long-acting injectables, in-situ forming gels, nanoparticle delivery systems, and controlled-release platforms. This ABA triblock architecture combines hydrophobic PCL end blocks with a hydrophilic PEG mid-block, providing amphiphilicity, thermo-responsive sol-gel transition, and biodegradability—ideal for complex drug delivery applications.
PCL-PEG-PCL is particularly suited for sustained release formulations due to the slow, predictable biodegradation of PCL and excellent compatibility with a wide range of APIs, including small molecules, peptides, and biologics.
Key Features & Technical Advantages
1. Thermo-Responsive Sol–Gel Behavior
PCL-PEG-PCL solutions are injectable as low-viscosity liquids at room or refrigerated temperature and form stable hydrogels at physiological temperature (~37°C).
This enables:
Subcutaneous and intramuscular depot formation
Long-acting release profiles ranging from days to months
Minimally invasive administration
Gelation temperature can be tuned by adjusting:
PEG block molecular weight
PCL block length
PCL:PEG:PCL ratio
2. Customizable Molecular Architecture
We provide fully tailored triblock copolymers to meet specific formulation requirements:
PEG mid-block MW: 1–20 kDa
PCL end-block MW: 2–150 kDa each
PCL:PEG ratio optimized for gelation, degradation, and mechanical strength
This allows control over:
Gelation kinetics and strength
Drug release profiles
Micelle/nanoparticle formation
Biodegradation rate
3. High-Purity Polymers with Advanced Characterization
Each batch undergoes rigorous analytical QC including:
GPC/SEC for molecular weight and dispersity
¹H/¹³C NMR for block length and composition
FTIR for structural confirmation
DSC/TGA for thermal properties
MALDI-TOF or HRMS (optional) for end-group verification
These data ensure suitability for CMC-driven formulation, ANDA complex generics, and NDA enabling research.
Applications
✔ In-Situ Forming Hydrogels for Long-Acting Injectables
PCL-PEG-PCL is ideal for controlled release of:
Peptides (GLP-1 analogs, leuprolide, octreotide)
Proteins and biologics
Small molecules and hydrophobic drugs
Its thermo-responsive gelation allows easy injection as a solution that forms a depot inside the body.
✔ Nanoparticles and Polymeric Carriers
The amphiphilic structure enables self-assembly into:
Micelles
Nanoparticles
Hybrid polymeric carriers
Providing enhanced:
API solubility
Encapsulation efficiency
Circulation half-life
✔ Long-Term Sustained Release
Slow degradation of PCL supports weeks to months drug release, making it suitable for:
Injectable depot systems
Implantable devices
Long-acting formulations
✔ Custom Polymer Development for Pharma R&D
We design PCL-PEG-PCL polymers for:
High-drug-loading nanocarriers
Combination therapies
Advanced formulation screening
CMC and preclinical development
Why Choose ResolveMass Laboratories Inc.?
✔ Expertise in Biodegradable Triblock Copolymers
We specialize in:
PCL-PEG-PCL
PEG-PCL
PLA-PEG-PLA
PLGA-PEG-PLGA
Fully customized polymer architectures
✔ Advanced Analytical Infrastructure
Our labs include:
High-field NMR
Triple-detector GPC
HRMS / MALDI-TOF
DSC/TGA
FTIR spectroscopy
✔ Formulation-Driven Polymer Engineering
Designed specifically for:
Complex generics
Long-acting injectables
Nanoparticle/micelle delivery
Novel drug delivery systems
Available Grades
Research grade
High-purity formulation development grade
Fully customized triblock configurations
Request Custom PCL-PEG-PCL Specifications
Our chemistry team can synthesize triblock copolymers with precise PCL end-block length, PEG mid-block MW, and PCL:PEG ratio tailored for your thermo-responsive gels or sustained-release formulations.