PEG-PCL
PEG-PCL (Poly(ethylene glycol)-b-poly(ε-caprolactone)) – Biodegradable Amphiphilic Block Copolymers for Nanoformulations and Drug Delivery
ResolveMass Laboratories Inc. offers high-purity PEG-PCL block copolymers engineered for nanoparticles, micelles, long-acting formulations, and controlled-release drug delivery systems. PEG-PCL is an amphiphilic AB or ABA block copolymer composed of hydrophilic PEG and hydrophobic PCL, enabling enhanced solubility, sustained release, and excellent biocompatibility for pharmaceutical R&D.
The slow, predictable biodegradation of PCL makes PEG-PCL particularly suitable for long-duration controlled release, depot systems, and nanoparticle formulations in complex generics and novel drug delivery projects.
Key Features & Technical Advantages
1. Amphiphilic Structure Ideal for Nanocarriers
PEG-PCL self-assembles into:
Polymeric micelles
Nanoparticles
Vesicles and hybrid nanocarriers
The hydrophobic PCL core encapsulates APIs, while PEG provides a sterically stabilizing shell.
This results in:
High drug-loading capacity
Enhanced solubility for hydrophobic APIs
Extended blood circulation
Reduced aggregation and opsonization
2. Slow, Tunable Biodegradation for Sustained Release
PCL degrades more slowly than PLA/PLGA, enabling weeks to months release durations.
We provide fully customizable:
PEG block MW: 1–20 kDa
PCL block MW: 2–150 kDa
PEG:PCL ratio optimized for your formulation needs
This tunability controls:
Release kinetics
Micelle size
Hydrophobic core stability
Degradation rate
3. High-Purity Polymers with Advanced Analytical Characterization
Each PEG-PCL polymer is rigorously characterized using:
GPC/SEC (universal calibration) for molecular weight & PDI
¹H/¹³C NMR for block length and end-group determination
FTIR for structural confirmation
MALDI-TOF or HRMS (optional) for end-group analysis
DSC/TGA for thermal properties & crystallinity evaluation
These QC elements support CMC-driven formulation development, NDA-enabling research, and ANDA complex generic studies.
Applications
✔ Nanoparticles & Polymeric Micelles for Solubility Enhancement
PEG-PCL is ideal for improving solubility and bioavailability of:
Hydrophobic oncology APIs
Immunomodulators
Lipophilic small molecules
The micelles typically fall within 20–150 nm, suitable for IV administration.
✔ Long-Acting Drug Delivery Systems
Due to the slow degradation of PCL, PEG-PCL supports:
Extended-release injectables
Implantable depots
Subcutaneous slow-releasing systems
Release periods can be engineered from weeks to several months.
✔ Biologics & Peptide Delivery
PEG-PCL enhances stability and protects sensitive molecules by creating:
Hydrophobic cores
PEG shielding for steric protection
✔ Custom Block Copolymers for Novel Delivery Platforms
We specialize in designing PEG-PCL for:
High-drug-loading nanocarriers
Dual-delivery systems
Combination formulation R&D
Polymer screening for CMC development
Why Choose ResolveMass Laboratories Inc.?
✔ Expertise in Biodegradable PEG-Based Polymers
We routinely synthesize:
PEG-PCL
mPEG-PCL
mPEG-PLA
mPEG-PLGA
PCL-PEG-PCL
Fully customized block copolymer architectures
✔ Advanced Analytical Infrastructure
Our labs feature:
Triple-detector GPC
High-field NMR
HRMS / LC-MS/MS
MALDI-TOF
FTIR, DSC, TGA
✔ Formulation-Oriented Polymer Engineering
Manufactured specifically for:
Complex generics
Nanoparticle and micelle systems
Long-acting injectable development
Novel drug delivery research
Available Grades
Research grade
High-purity formulation grade
Fully customized block-length and ratio configurations
Request Custom PEG-PCL Specifications
Our chemistry team can synthesize tailored PEG-PCL polymers with precise molecular weights, ratios, and end-group chemistry to meet your project’s formulation and CMC needs.