PLA-PCL
PLA-PCL Block Copolymers – Biodegradable Amphiphilic Polymers for Advanced Drug Delivery
ResolveMass Laboratories Inc. offers high-purity PLA-PCL block copolymers, engineered for nanoparticles, micelles, long-acting formulations, and controlled-release drug delivery systems. PLA-PCL combines hydrophobic PLA and PCL segments in an amphiphilic or block architecture, providing tunable degradation rates, mechanical strength, and drug release properties suitable for complex generic and novel drug delivery projects.
PLA-PCL is particularly valuable in formulations requiring sustained release, biocompatibility, and predictable biodegradation for small molecules, peptides, and biologics.
Key Features & Technical Advantages
1. Amphiphilic Architecture for Nanocarriers
PLA-PCL self-assembles into:
Polymeric micelles
Nanoparticles
Vesicles or hybrid nanocarriers
Hydrophobic PLA and PCL segments form the core for API encapsulation, while the amphiphilic balance enhances:
Solubility of hydrophobic drugs
Particle stability
Circulation half-life
Reduced aggregation
2. Tunable Biodegradation and Release Profiles
PLA-PCL offers controllable degradation kinetics by adjusting:
PLA:PCL block ratio
Molecular weight of PLA and PCL blocks
This allows for:
Tailored sustained-release profiles (days to months)
Optimized mechanical and thermal properties
Controlled polymer crystallinity for depot formulations
Typical ranges:
PLA block MW: 2–100 kDa
PCL block MW: 2–150 kDa
Block ratios customizable per project
3. High Purity & Advanced Analytical QC
Each batch is thoroughly characterized using:
GPC/SEC for molecular weight and dispersity
¹H/¹³C NMR for block composition and structure
FTIR for polymer identity
DSC/TGA for thermal properties
MALDI-TOF or HRMS (optional) for end-group verification
These quality controls ensure compatibility with CMC-driven formulation development, ANDA complex generics, and NDA enabling R&D.
Applications
✔ Nanoparticles & Polymeric Micelles
PLA-PCL is ideal for forming stable nanocarriers for:
Hydrophobic small molecules
Peptides and biologics
Solubility enhancement and improved bioavailability
✔ Long-Acting and Sustained Release Formulations
Due to the slow, tunable degradation of PCL and PLA, PLA-PCL supports:
Injectable depots
Implantable formulations
Extended-release therapeutic delivery
✔ Biocompatible Drug Delivery Platforms
PLA-PCL degradation yields non-toxic lactic acid and caproic acid, ensuring safe in vivo applications.
✔ Custom Block Copolymers for Pharma R&D
ResolveMass Laboratories offers tailored PLA-PCL synthesis for:
Specific degradation kinetics
High drug-loading nanocarriers
Controlled-release depot systems
Formulation screening and preclinical studies
Why Choose ResolveMass Laboratories Inc.?
✔ Expertise in Biodegradable Block Copolymers
We routinely synthesize:
PLA-PCL
PCL-PEG-PCL
PLA-PEG-PLA
PEG-PCL
Fully customized polymer architectures
✔ Advanced Analytical Infrastructure
Our laboratories include:
High-field NMR
Triple-detector GPC
HRMS / MALDI-TOF
DSC/TGA
FTIR spectroscopy
✔ Formulation-Oriented Polymer Engineering
Designed specifically for:
Complex generic R&D
Long-acting injectable development
Nanoparticle/micelle delivery
Novel drug delivery system innovation
Available Grades
Research grade
High-purity formulation development grade
Fully customized block-length and ratio configurations
Request Custom PLA-PCL Specifications
Our chemistry team can synthesize PLA-PCL polymers with precise block lengths, ratios, and molecular weight distributions tailored to your nanoparticle, depot, or sustained-release formulation needs.