PLA-PEG-PLA
PLA-PEG-PLA Triblock Copolymer – Biodegradable Thermo-Responsive Polymers for Advanced Drug Delivery Systems
ResolveMass Laboratories Inc. offers high-purity PLA-PEG-PLA triblock copolymers, engineered for in-situ gelling formulations, nanoparticle delivery systems, long-acting injectables, and sustained-release platforms. This ABA triblock architecture features hydrophobic PLA end blocks and a hydrophilic PEG mid-block, forming a biodegradable, amphiphilic polymer ideally suited for controlled-release drug formulations.
PLA-PEG-PLA is known for its thermo-responsive sol–gel behavior, biodegradability into non-toxic byproducts, and high compatibility with small molecules, peptides, proteins, and biologics.
Key Features & Technical Advantages
1. Thermo-Responsive Sol–Gel Transition
PLA-PEG-PLA solutions remain low-viscosity at room or refrigerated temperatures, allowing easy injection. At physiological temperature (~37°C), they form a stable hydrogel depot.
This property enables:
Long-acting subcutaneous and intramuscular depots
Sustained release ranging from days to months
Minimally invasive administration
The gelation temperature can be precisely tuned by adjusting:
PEG molecular weight
PLA block length
PLA:PEG:PLA ratio
2. Highly Customizable Molecular Architecture
We offer full customization to match your formulation needs:
PEG block MW: 1–20 kDa
PLA block MW: 2–100 kDa each (A blocks)
Lactide stereochemistry: L-, D-, or racemic
This tunability allows control of:
Gel strength
Degradation rate
Mechanical integrity
Drug release kinetics
3. High-Purity Polymers with Advanced Analytical QC
Each batch is characterized using:
GPC/SEC with universal calibration for Mn and dispersity
¹H/¹³C NMR to confirm block composition & purity
FTIR for polymer identity verification
DSC/TGA to assess thermal transitions
MALDI-TOF or HRMS (optional) for end-group analysis
These data support CMC-driven formulation, ANDA complex generics, and NDA enabling R&D.
Applications
✔ In-Situ Forming Hydrogels for Long-Acting Injectables
Ideal for controlled release of:
Peptides (octreotide, GLP-1 analogs, leuprolide)
Proteins and biologics
Small molecules
Oligonucleotides
The thermosensitive behavior allows formulation as a low-viscosity liquid that forms a gel depot inside the body.
✔ Nanoparticles, Micelles & Polymeric Carriers
The amphiphilic PLA-PEG-PLA structure self-assembles into:
Micelles
Nanoparticles
Hybrid polymeric carriers
Providing improved:
API solubility
Encapsulation efficiency
Circulation half-life
✔ Implantable & Injectable Depot Systems
The degradable PLA blocks offer predictable breakdown to lactic acid, enabling:
Long-term controlled release
Tissue-compatible implants
Minimally invasive therapeutic delivery
✔ Custom Polymer Development for Pharma R&D
We specialize in creating tailored block lengths, ratios, and stereochemistry for advanced formulation studies.
Why Choose ResolveMass Laboratories Inc.?
✔ Leading Expertise in Biodegradable Triblock Copolymers
We routinely synthesize:
PLA-PEG-PLA
PLGA-PEG-PLGA
PCL-PEG-PCL
mPEG-PLA and mPEG-PLGA
✔ Comprehensive Analytical Infrastructure
Our labs offer:
High-field NMR
Triple-detector GPC
HRMS & MALDI-TOF
Thermal analysis
FTIR structural confirmation
✔ Formulation-Driven Polymer Engineering
Designed specifically for:
Complex generic R&D
LAI and depot technologies
Polymer screening for CMC
Novel drug delivery innovations
Available Grades
Research grade
High-purity formulation development grade
Fully customized triblock systems
Request Custom PLA-PEG-PLA Specifications
Our chemistry team can design the exact molecular architecture—PLA block lengths, PEG MW, stereochemistry, and degradation profile—to match your in-situ gelling or controlled-release formulation needs.