1-Aminoadamantane-d15 | CAS 33830-10-3

OVERVIEW  of  1-Aminoadamantane-d15 | CAS 33830-10-3

1-Aminoadamantane-d₁₅ (CAS 33830-10-3) is a fully deuterated analog of 1-aminoadamantane (amantadine), in which all fifteen hydrogen atoms of the adamantane framework are replaced with deuterium. This isotopic substitution produces a mass shift of +15 Da, enabling the compound to serve as a stable isotope-labeled internal standard for mass spectrometry and analytical studies.

Owing to its structural and chemical equivalence to amantadine, 1-aminodamantane-d₁₅ is widely used in pharmacokinetic, metabolic, and bioanalytical research, as well as in LC-MS/MS quantification of amantadine in biological matrices such as plasma, serum, or urine.

CHEMICAL INFORMATION

• Name: 1-Aminoadamantane-d₁₅

• Molecular Formula: C₁₀D₁₅N

• Molecular Weight: 166.34 g/mol

• CAS Number: 33830-10-3

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated adamantane amine; stable isotope-labeled pharmaceutical reference

• Stability: Chemically and isotopically stable under recommended storage conditions

APPLICATIONS  of  1-Aminoadamantane-d15 | CAS 33830-10-3

• Pharmacokinetic and Metabolic Studies:
  Used as a reference standard in the analysis of amantadine absorption, distribution, metabolism, and excretion profiles in biological systems.

• Analytical Chemistry (LC-MS/MS):
  Serves as an internal standard for the accurate quantification of amantadine in complex biological samples.

• Drug Development and Validation:
  Assists in method development, validation, and stability testing for pharmaceutical formulations and bioequivalence studies.

• Forensic and Toxicology Research:
  Employed in the detection and quantification of amantadine in forensic toxicology or clinical pharmacology.

• Isotopic Tracer Studies:
  Utilized in metabolic labeling experiments and reaction mechanism investigations involving adamantane derivatives.

ADVANTAGES  of  1-Aminoadamantane-d15 | CAS 33830-10-3

• Provides excellent mass distinction (+15 Da) from the unlabeled compound.

• Identical chromatographic and ionization behavior ensures accurate internal standardization.

• Non-radioactive, safe, and stable for long-term use.

• Enhances precision and reproducibility in quantitative LC-MS/MS assays.

• Ideal for regulatory and research-grade analytical applications.

HANDLING, STORAGE & SAFETY

• Handling: Handle with clean, dry equipment in a controlled environment to prevent contamination.

• Storage: Store at –20 °C, tightly sealed, and protected from light and moisture.

• Safety: Non-hazardous and non-radioactive; handle using general laboratory safety practices.

• Disposal: Dispose of in accordance with institutional and environmental regulations for organic chemicals.

QUALITY & SPECIFICATION

• Chemical Purity: ≥ 98 %

• Isotopic Enrichment: ≥ 98 atom % D

• Form: Crystalline or powder

• Analytical Characterization: Verified by NMR and LC-MS

• Documentation: Certificate of Analysis (CoA) provided for each batch, confirming isotopic enrichment and purity

SUMMARY
1-Aminoadamantane-d₁₅ (CAS 33830-10-3) is a high-purity, fully deuterated analog of amantadine, specifically designed for quantitative mass spectrometry and pharmacokinetic studies. Its complete deuteration ensures reliable isotopic differentiation while maintaining identical physicochemical and chromatographic properties to the native compound. This makes it indispensable in bioanalytical method validation, pharmaceutical research, and clinical quantification of amantadine and related compounds.

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