1,4-Butanedioic-d4 Acid | CAS 14493-42-6

OVERVIEW  of  1,4-Butanedioic-d4 Acid | CAS 14493-42-6

1,4-Butanedioic-d₄ acid (CAS 14493-42-6) is the fully deuterated analog of succinic acid, a key intermediate in various biochemical and industrial processes. With four deuterium atoms replacing the hydrogen atoms on the carbon backbone, this isotopically labeled compound provides distinct advantages in mass spectrometry (MS), NMR spectroscopy, and stable isotope labeling studies. Its high deuterium enrichment enables precise quantification and tracing of succinate and related metabolites in biological and environmental systems.

CHEMICAL INFORMATION

• Name: 1,4-Butanedioic-d₄ acid

• Molecular Formula: C₄D₄O₄

• Molecular Weight: 122.05 g/mol

• CAS Number: 14493-42-6

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated aliphatic dicarboxylic acid

• Solubility: Soluble in water, ethanol, and methanol

APPLICATIONS  of  1,4-Butanedioic-d4 Acid | CAS 14493-42-6

• Mass Spectrometry (MS) Internal Standard:
  Commonly used as an internal or calibration standard in GC-MS and LC-MS techniques for quantitative analysis of succinic acid in complex biological and environmental matrices.

• Stable Isotope Labeling Studies:
  Facilitates metabolic flux analysis and pathway elucidation by tracking the fate of succinate and related intermediates in the citric acid (TCA) cycle and other metabolic pathways.

• Biochemical and Metabolomic Research:
  Used to study energy metabolism, mitochondrial function, and redox balance, especially in cellular respiration and oxidative stress models.

• NMR Spectroscopy:
  Acts as a deuterated reference compound or solvent standard in proton-decoupled NMR experiments, enhancing signal clarity and spectral interpretation.

• Environmental and Industrial Chemistry:
  Applied in the study of biodegradation, organic acid analysis, and carbon flux tracing in environmental monitoring and industrial bioprocesses.

ADVANTAGES  of  1,4-Butanedioic-d4 Acid | CAS 14493-42-6

• High isotopic enrichment ensures accurate and reproducible isotope ratio measurements.

• Chemically identical to natural succinic acid, allowing direct metabolic substitution.

• Stable under normal laboratory conditions and compatible with diverse analytical systems.

• Enables precise mass spectral differentiation from native compounds, improving quantification accuracy.

HANDLING AND SAFETY

• Handling Precautions: Avoid inhalation and contact with eyes or skin; use in a well-ventilated laboratory area.

• Protective Equipment: Gloves, lab coat, and safety glasses recommended.

• Storage: Store in a tightly sealed container in a cool, dry place.

• Stability: Stable at room temperature; avoid excessive heat and moisture.

• Disposal: Dispose of according to institutional chemical waste management protocols.

SUMMARY
1,4-Butanedioic-d₄ acid (CAS 14493-42-6) is a high-purity, fully deuterated form of succinic acid ideal for analytical, biochemical, and environmental research applications. Its exceptional isotopic labeling precision and chemical stability make it a preferred choice for quantitative mass spectrometry, metabolic pathway analysis, and reference standard use in both academic and industrial laboratories.

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