Carbazole-d8, NH | CAS 38537-24-5

OVERVIEW
Carbazole-d₈, NH is a fully deuterated analogue of carbazole in which all eight aromatic hydrogen atoms are replaced with deuterium, while the NH proton remains unaltered. This isotopic substitution imparts a +8 Da molecular mass shift without altering the compound’s fundamental structure, reactivity, or spectroscopic properties.

As a high-purity stable isotope-labelled compound, Carbazole-d₈, NH is widely used in analytical chemistry, environmental science, materials research, and spectroscopic applications. Its identical chemical behavior and distinct isotopic signature make it an indispensable internal standard for quantitative mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and combustion or pyrolysis studies.

The compound’s high isotopic enrichment, chemical stability, and reproducibility ensure superior performance in analytical calibration, isotope effect research, and synthetic chemistry involving carbazole-based molecules. Produced under controlled isotopic exchange conditions, Carbazole-d₈, NH from ResolveMass Laboratories Inc. meets the strict requirements of precision-oriented laboratories engaged in advanced research and analytical testing.

CHEMICAL INFORMATION

• Name: Carbazole-d₈, NH

• Molecular Formula: C₁₂D₈NH

• Molecular Weight: 175.26 g/mol

• Isotopic Enrichment: ≥ 98 atom % D

• CAS Number: 38537-24-5

• Stability: Chemically stable under normal conditions; sensitive to strong oxidizing agents

Carbazole-d₈, NH retains the planar tricyclic aromatic structure characteristic of carbazole, comprising two fused benzene rings connected through a nitrogen-containing five-membered ring. The replacement of all aromatic hydrogens with deuterium provides mass differentiation while preserving the electronic and molecular integrity of the compound.

APPLICATIONS Of Carbazole-d8, NH | CAS 38537-24-5
Carbazole-d₈, NH is a versatile stable isotope-labelled compound extensively employed in analytical and research settings for method development, structural elucidation, and isotope effect studies. Its major areas of application include:

1. Internal Standard for Mass Spectrometry (MS):
   The compound is used as an isotopically labelled internal standard in GC-MS and LC-MS analyses of carbazole and related aromatic nitrogen heterocycles. Its mass difference (M+8) allows accurate differentiation and quantification of carbazole in complex matrices, supporting high-precision analytical measurements.

2. NMR Spectroscopy:
   Carbazole-d₈, NH serves as an NMR reference and solvent standard, minimizing proton background signals in ^1H NMR and enabling improved spectral resolution. It is also used to study hydrogen–deuterium exchange kinetics and isotopic effects in aromatic systems.

3. Environmental Monitoring:
   Carbazole and its derivatives are environmental pollutants resulting from coal tar, petroleum refining, and combustion processes. Carbazole-d₈, NH is used as a labelled tracer for monitoring carbazole contamination and degradation in soil, sediment, and atmospheric samples.

4. Toxicological Studies:
   In toxicokinetic and metabolism studies, Carbazole-d₈, NH helps trace the fate and transformation of carbazole and related polycyclic aromatic compounds in biological systems, aiding in risk assessment and exposure analysis.

5. Material Science and Organic Electronics:
   Carbazole derivatives are important components in optoelectronic materials such as OLEDs, photoconductors, and hole-transport materials. The deuterated variant is employed to investigate isotope effects on charge transport, stability, and photophysical behavior in such devices.

6. Isotope Effect and Mechanistic Research:
   In physical and organic chemistry, Carbazole-d₈, NH is valuable for examining kinetic isotope effects, reaction mechanisms, and hydrogen transfer dynamics. Deuterium substitution provides insight into bond strength and reaction energetics in aromatic systems.

7. Combustion and Pyrolysis Studies:
   Due to its high thermal stability and aromatic structure, the compound is utilized as a reference material in studies examining the combustion behavior of nitrogen-containing polycyclic compounds.

ADVANTAGES

• High Isotopic Purity: Manufactured with ≥ 98 atom % D, ensuring superior isotopic integrity and accurate analytical results.

• Complete Deuteration (Aromatic Positions): Provides a uniform mass shift while retaining the native NH group for hydrogen-exchange investigations.

• Chemical Equivalence: Exhibits identical physicochemical and chromatographic properties to non-deuterated carbazole, ensuring precise analytical correlation.

• Distinct Mass Shift (M+8): Offers clear mass differentiation for isotope ratio studies and MS quantification.

• Excellent Thermal and Chemical Stability: Suitable for high-temperature and high-energy analytical methods.

• Broad Analytical Compatibility: Effective in NMR, MS, environmental analysis, and advanced material characterization.

HANDLING
Carbazole-d₈, NH should be handled according to standard laboratory safety protocols. While the compound is relatively stable and of low acute toxicity, prolonged or repeated exposure may cause irritation or sensitization.

• Work in a well-ventilated environment or fume hood.

• Avoid inhalation of dust and contact with skin or eyes.

• Use protective gloves, safety goggles, and lab coat.

• Avoid exposure to strong acids, oxidizing agents, or UV light.

QUALITY & DOCUMENTATION
All stable isotope-labelled compounds from ResolveMass Laboratories Inc. are synthesized and purified under rigorous quality assurance systems to ensure consistent isotopic composition, purity, and identity. Carbazole-d₈, NH is analytically verified through NMR, MS, and IR techniques prior to release.

Each batch is accompanied by comprehensive documentation, including:

• Certificate of Analysis (COA): Detailing isotopic enrichment, purity, and analytical verification.

• Safety Data Sheet (SDS): Providing handling and hazard information.

• Batch Traceability: Ensuring full compliance and reproducibility for regulated and research applications.

ResolveMass Laboratories Inc. maintains a commitment to providing premium-quality deuterated and isotopically labelled reference materials for cutting-edge scientific and industrial research.

SUMMARY
Carbazole-d₈, NH is a high-purity, fully deuterated aromatic nitrogen heterocycle designed for advanced analytical and research applications. Combining high isotopic enrichment, excellent thermal stability, and chemical fidelity, it enables accurate, reproducible, and traceable measurements across multiple disciplines — from mass spectrometry and NMR to environmental science and materials research.

By delivering superior isotopic quality and documentation, ResolveMass Laboratories Inc. ensures that Carbazole-d₈, NH stands as a trusted standard for laboratories dedicated to precision isotope analysis, mechanistic chemistry, and analytical innovation.