Dimethyl Phthalate-3,4,5,6-d4 | CAS 93951-89-4

OVERVIEW  of  Dimethyl Phthalate-3,4,5,6-d4 | CAS 93951-89-4

Dimethyl Phthalate-3,4,5,6-d₄ (DMP-d₄) is a deuterium-labeled analogue of dimethyl phthalate, a compound widely used as a plasticizer, solvent, and chemical intermediate across numerous industries. Because dimethyl phthalate is frequently detected in environmental samples, consumer products, indoor air, surface waters, and biological matrices, the availability of a stable isotope-labeled internal standard is critical for accurate monitoring and regulatory analysis. DMP-d₄ contains four deuterium atoms strategically incorporated into the aromatic ring, producing a clear mass shift while preserving the native compound’s extraction behavior, chromatographic retention, and ionization characteristics.

The chemical and physical similarity between DMP and DMP-d₄ ensures highly reliable isotope-dilution quantification, even within complex or contaminated sample matrices. This makes DMP-d₄ an indispensable tool for laboratories performing advanced environmental monitoring, toxicological testing, consumer product evaluation, and method validation in both GC-MS and LC-MS workflows. Its stability, reproducibility, and broad compatibility with analytical platforms offer significant advantages for long-term use in regulated and research environments.

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CHEMICAL INFORMATION

• Name: Dimethyl phthalate-d₄

• Molecular Formula: C₁₀H₆D₄O₄

• Molecular Weight: 198.21 g/mol

• CAS Number: 93951-89-4

• Isotopic Enrichment: Typically ≥98% D

• Chemical Class: Deuterated aromatic diester (phthalate)

• Stability: Stable under ambient laboratory conditions; resistant to degradation under neutral pH

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APPLICATIONS  of  Dimethyl Phthalate-3,4,5,6-d4 | CAS 93951-89-4
Dimethyl Phthalate-d₄ is used across a wide range of analytical and research fields:

• Internal Standard for GC-MS and LC-MS:
  DMP-d₄ is ideal for isotope-dilution quantification of dimethyl phthalate in products, materials, and environmental samples. Its mass shift enables accurate correction of matrix effects, signal suppression, and extraction inefficiencies.

• Environmental Monitoring and Pollutant Tracking:
  Used to assess phthalate contamination in soil, sediment, wastewater, drinking water, indoor dust, and atmospheric aerosols. DMP-d₄ supports ultra-trace screening and long-term environmental surveillance.

• Consumer Goods and Packaging Analysis:
  Frequently employed to monitor phthalate migration from plastics, coatings, packaging materials, toys, and personal care products.

• Industrial Quality Control:
  Facilitates the validation of phthalate-free manufacturing processes and helps maintain compliance with industry and regulatory requirements.

• Toxicology and Human Exposure Studies:
  Used to trace metabolic pathways, evaluate human exposure, and support biomonitoring programs by providing a stable isotopic reference.

• Analytical Method Development:
  Plays a central role in calibration, recovery studies, precision/accuracy assessments, and establishing detection/quantification limits for new analytical methods.

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ADVANTAGES  of  Dimethyl Phthalate-3,4,5,6-d4 | CAS 93951-89-4

• Superior Mass Spectral Differentiation:
  The four deuterium atoms deliver a predictable mass shift that cleanly separates DMP-d₄ from native dimethyl phthalate during MS analysis.

• Exceptional Chemical Equivalence:
  Mirrors the chromatographic behavior and ionization efficiency of the unlabeled compound, ensuring highly reliable internal standard performance.

• Enhanced Quantitative Accuracy:
  Minimizes variability across sample types and instrument configurations, especially in low-level and trace-contaminant testing.

• Improved Method Robustness:
  Supports consistent calibration and validation across multiple runs, operators, and instruments.

• Broad Analytical Compatibility:
  Functions seamlessly in both GC-MS and LC-MS workflows, including high-resolution mass spectrometry platforms.

• Stable and Long-Lasting:
  Maintains chemical integrity over extended storage periods and repeated analytical cycles.

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SUMMARY
Dimethyl Phthalate-3,4,5,6-d₄ is a high-quality, deuterium-enriched internal standard designed to meet the rigorous analytical demands of environmental, industrial, toxicological, and consumer product laboratories. With its excellent chemical stability and precise isotopic labeling, DMP-d₄ enables accurate quantification of dimethyl phthalate even in challenging matrices. Its compatibility with major analytical techniques and its critical role in method validation, pollutant monitoring, and regulatory compliance make it an essential reference material for modern analytical workflows. For laboratories committed to accurate, reproducible, and defensible phthalate analysis, DMP-d₄ offers unmatched reliability and performance.

 

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