OVERVIEW of Dodecanoic-d23-acid | CAS 59154-43-7
Dodecanoic-d₂₃-acid, also known as lauric-d₂₃ acid, is a fully deuterated form of dodecanoic acid (lauric acid), a medium-chain saturated fatty acid widely found in natural fats and oils such as coconut oil and palm kernel oil. In this isotopically enriched compound, nearly all hydrogen atoms (23 total) are replaced with deuterium, giving it the chemical formula C₁₂D₂₃O₂ and a molecular weight of approximately 203.40 g/mol.
This compound retains the same chemical structure and physicochemical properties as its non-deuterated counterpart but exhibits a distinct mass shift due to the substitution of deuterium for hydrogen. This isotopic difference makes Dodecanoic-d₂₃-acid an essential standard and tracer molecule in advanced analytical, biochemical, and pharmaceutical research applications.
Deuterated fatty acids like Dodecanoic-d₂₃-acid are fundamental to modern mass spectrometry (MS), lipidomics, and metabolomics workflows, enabling researchers to precisely quantify, trace, and distinguish native lipid species in complex biological matrices. As a stable isotope-labeled standard, it plays a crucial role in understanding lipid metabolism, dietary fat utilization, and biochemical transformations involving medium-chain fatty acids.
CHEMICAL INFORMATION
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Name: Dodecanoic-d₂₃-acid
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CAS Number: 59154-43-7
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Molecular Formula: C₁₂D₂₃O₂
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Molecular Weight: 223.46 g/mol
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Isotopic Enrichment: ≥98 atom % D
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Chemical Class: Deuterated medium-chain saturated fatty acid
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Solubility: Insoluble in water; soluble in organic solvents such as chloroform, hexane, and ethanol
APPLICATIONS of Dodecanoic-d23-acid | CAS 59154-43-7
Dodecanoic-d₂₃-acid is extensively used in a variety of scientific and industrial research fields. Its isotopic labeling allows for precise analytical tracking and quantification of fatty acid species in both biological and synthetic systems. Major application areas include:
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Mass Spectrometry Internal Standard:
Used as a high-accuracy internal standard in GC-MS, LC-MS, and LC-MS/MS methods for the quantification of lauric acid and other medium-chain fatty acids. The deuterated analog provides distinct isotopic peaks, ensuring reliable differentiation from the native compound. -
Lipidomics and Metabolomics:
Plays a key role in quantitative lipidomic profiling and metabolic studies of fatty acid composition in biological samples such as plasma, liver, and adipose tissue. Facilitates accurate measurement of lipid turnover, oxidation, and biosynthesis rates. -
Metabolic Flux Analysis:
Ideal for stable isotope labeling experiments to study fatty acid metabolism, β-oxidation, and lipid remodeling pathways in cell cultures or in vivo models. The deuterium label provides a clear isotopic signature that enables precise tracing of metabolic fates. -
Nutritional and Biomedical Research:
Enables in-depth investigation of dietary fat absorption, transport, and oxidation in metabolic studies. Provides insights into lipid utilization and energy regulation in nutritional biochemistry and clinical research. -
Pharmaceutical and Toxicology Studies:
Used in pharmacokinetic and metabolic profiling of drug–lipid interactions. Serves as a model compound to assess xenobiotic metabolism involving lipid conjugates and fatty acid-modified drug delivery systems. -
Method Development and Validation:
Employed as a calibration and performance standard to validate chromatographic and mass spectrometric methods for fatty acid analysis, ensuring consistency and reproducibility in analytical workflows.
ADVANTAGES of Dodecanoic-d23-acid | CAS 59154-43-7
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High Isotopic and Chemical Purity: Ensures accurate isotopic separation and reliable analytical results.
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Excellent Thermal and Chemical Stability: Maintains structural integrity during derivatization, chromatographic separation, and detection.
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Quantitative Precision: Facilitates isotope dilution-based quantification, reducing matrix effects and improving reproducibility.
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Versatile Analytical Compatibility: Suitable for GC, LC, GC-MS, and LC-MS/MS techniques across a wide range of sample types.
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Biologically Relevant Analog: Mimics the physical and chemical behavior of natural lauric acid, allowing for meaningful metabolic correlation.
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Long-Term Storage Stability: Stable under recommended storage conditions, minimizing isotopic degradation and oxidation.
SUMMARY
Dodecanoic-d₂₃-acid (CAS 59154-43-7) is a highly purified, fully deuterated analog of lauric acid specifically designed for advanced analytical and biochemical studies. Its substitution of deuterium atoms for hydrogen creates a distinct isotopic profile, making it an indispensable tool in quantitative lipidomics, metabolomics, nutritional research, and pharmaceutical development.
At ResolveMass Laboratories Inc., Dodecanoic-d₂₃-acid is manufactured under stringent quality controls to ensure superior isotopic enrichment and chemical purity, meeting the demands of modern research and analytical laboratories. It provides researchers with unparalleled precision and confidence in fatty acid quantification, metabolic tracing, and lipid pathway elucidation.
By integrating this deuterated fatty acid into experimental protocols, scientists can uncover detailed insights into lipid dynamics, metabolism, and energy utilization, enabling the development of improved diagnostic tools, nutritional strategies, and therapeutic solutions.
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