Morpholine-2,2,3,3,5,5,6,6-d8 | CAS 342611-02-3

OVERVIEW  of  Morpholine-2,2,3,3,5,5,6,6-d8 | CAS 342611-02-3

Morpholine-2,2,3,3,5,5,6,6-d₈ (CAS 342611-02-3) is a fully deuterated analog of morpholine, in which all eight ring hydrogens are replaced by deuterium. This compound serves as an essential isotopically labeled reagent in analytical chemistry, pharmaceutical research, and environmental monitoring. Its structural and chemical behavior closely mirrors that of non-deuterated morpholine, allowing it to be used as a stable internal standard in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies for accurate quantification and spectral analysis.

CHEMICAL INFORMATION

• Name: Morpholine-d₈

• Molecular Formula: C₄D₈NO

• Molecular Weight: 95.17 g/mol

• CAS Number: 342611-02-3

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic amine

• Solubility: Completely miscible with water, ethanol, and most polar solvents

APPLICATIONS  of  Morpholine-2,2,3,3,5,5,6,6-d8 | CAS 342611-02-3

• Mass Spectrometry (MS):
  Used as a stable isotope-labeled internal standard for quantifying morpholine and related amines in environmental, pharmaceutical, and industrial samples.

• Nuclear Magnetic Resonance (NMR):
  Acts as a deuterated reference compound that minimizes proton interference and improves spectral resolution, especially in heterocyclic compound analysis.

• Pharmaceutical Research:
  Employed in metabolic and pharmacokinetic studies to trace morpholine-derived intermediates in drug development and formulation.

• Environmental and Industrial Monitoring:
  Useful in pollutant tracking and analytical calibration for studies involving morpholine contamination or degradation products.

• Synthetic Chemistry:
  Serves as a deuterated building block for the preparation of isotopically labeled morpholine derivatives and related heterocyclic compounds.

ADVANTAGES  of  Morpholine-2,2,3,3,5,5,6,6-d8 | CAS 342611-02-3

• High isotopic purity (≥ 98 atom % D) ensures distinct mass separation in MS analyses.

• Stable and non-radioactive isotope labeling enhances safety and reproducibility.

• Chemically identical to morpholine, allowing direct comparison and substitution in analytical protocols.

• Reduces background noise and enhances clarity in both NMR and MS spectra.

HANDLING AND SAFETY

• Handling: Use in a well-ventilated area; avoid direct contact with eyes, skin, and clothing.

• Storage: Keep tightly sealed and stored at 2–8 °C; avoid prolonged exposure to air or light.

• Safety: May cause irritation; appropriate personal protective equipment (gloves, goggles, and lab coat) is recommended.

• Disposal: Dispose of according to local and institutional chemical waste guidelines.

SUMMARY
Morpholine-2,2,3,3,5,5,6,6-d₈ (CAS 342611-02-3) is a high-purity, deuterium-labeled analog of morpholine used widely in mass spectrometry, NMR spectroscopy, and tracer studies. Its stability, isotopic precision, and identical reactivity to the non-deuterated compound make it an indispensable analytical standard in chemical, environmental, and pharmaceutical research applications.