Tetradecanoic-d27-acid | CAS 60658-41-5

OVERVIEW  of  Tetradecanoic-d27-acid | CAS 60658-41-5

Tetradecanoic-d₂₇-acid, commonly known as myristic-d₂₇ acid, is a fully deuterated form of the naturally occurring saturated fatty acid, myristic acid (C₁₄H₂₈O₂). In this isotopically enriched variant, all 27 hydrogen atoms are substituted with deuterium, resulting in a molecular formula of C₁₄D₂₇O₂ and a molecular weight of approximately 231.45 g/mol. The compound is chemically and structurally equivalent to natural myristic acid, with the key distinction being its isotopic composition. This deuterium labeling provides a unique and detectable mass shift that is highly valuable in analytical and biochemical applications.

As a stable isotope-labeled fatty acid, Tetradecanoic-d₂₇-acid is extensively used in mass spectrometry (MS), lipidomics, metabolomics, and stable isotope tracing experiments. Because myristic acid is a fundamental component of lipids, phospholipids, and acylated proteins in biological systems, its deuterated counterpart enables precise quantification, tracing, and differentiation of endogenous lipid species in complex biological samples.

This compound is particularly important in quantitative lipid profiling, metabolic flux studies, nutritional biochemistry, and pharmaceutical research, where accurate measurement of fatty acid metabolism and incorporation is required.

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CHEMICAL INFORMATION

• Name: Tetradecanoic-d₂₇-acid

• CAS Number: 60658-41-5

• Molecular Formula: C₁₄D₂₇O₂

• Molecular Weight: 255.54 g/mol

• Isotopic Enrichment: ≥98 atom % D

• Chemical Class: Deuterated long-chain saturated fatty acid

• Solubility: Insoluble in water; soluble in organic solvents such as chloroform, methanol, and ethanol

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APPLICATIONS  of  Tetradecanoic-d27-acid | CAS 60658-41-5
Tetradecanoic-d₂₇-acid serves as a crucial analytical and biochemical tool across multiple scientific domains:

• Mass Spectrometry Internal Standard:
  Utilized as an internal or surrogate standard in GC-MS and LC-MS/MS analyses for accurate quantification of myristic acid and related medium-chain fatty acids. Its distinct isotopic mass difference allows clear separation from the native analyte signal.

• Lipidomics and Metabolomics:
  Plays a key role in quantitative lipidomic workflows, allowing precise determination of lipid concentrations and turnover rates in biological samples such as serum, plasma, adipose tissue, and cell extracts.

• Metabolic Flux and Tracer Studies:
  Used in isotope tracing experiments to study fatty acid synthesis, oxidation, and elongation pathways in both in vitro and in vivo systems. Deuterium labeling enables accurate tracking of lipid metabolism and incorporation dynamics.

• Biochemical and Nutritional Research:
  Facilitates the study of dietary fat absorption, lipid biosynthesis, and lipid–protein interactions, providing valuable insights into energy metabolism and lipid regulation.

• Pharmaceutical and Toxicological Applications:
  Employed in pharmacokinetic studies and in the evaluation of drug–lipid interactions, as well as in assessing the metabolic fate of xenobiotics involving fatty acid conjugates.

• Calibration and Method Validation:
  Serves as a reference standard for analytical method development and validation, ensuring precision and reproducibility in quantitative MS assays.

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ADVANTAGES  of  Tetradecanoic-d27-acid | CAS 60658-41-5

• High Isotopic Purity (≥98 atom % D): Ensures consistent mass spectrometric separation and analytical reliability.

• Enhanced Quantification Accuracy: Facilitates isotope dilution quantification by serving as a structurally identical but isotopically distinct internal standard.

• Thermally and Chemically Stable: Maintains integrity during sample preparation, derivatization, and chromatographic analysis.

• Broad Analytical Compatibility: Suitable for GC, GC-MS, LC, and LC-MS/MS techniques.

• Biological Relevance: Mimics the physiological behavior of native myristic acid, enabling direct correlation between labeled and endogenous metabolites.

• Excellent Storage Stability: Resistant to oxidation and degradation when stored under recommended conditions.

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SUMMARY
Tetradecanoic-d₂₇-acid (CAS 60658-41-5) is a high-purity, fully deuterated analog of myristic acid specifically engineered for use in precision analytical and biochemical research. Its isotopic labeling allows scientists to perform quantitative lipid profiling, metabolic pathway elucidation, and stable isotope labeling experiments with superior accuracy and reproducibility.

At ResolveMass Laboratories Inc., Tetradecanoic-d₂₇-acid is produced to the highest isotopic and chemical purity standards to meet the demands of modern analytical laboratories. Its consistent performance in lipidomics, metabolomics, and environmental chemistry makes it an indispensable reference compound for both fundamental and applied research.

By integrating this deuterated fatty acid into analytical workflows, researchers gain improved sensitivity, specificity, and reliability in quantifying fatty acids and understanding metabolic processes — ultimately advancing knowledge in areas such as nutrition, health, and energy metabolism.

 

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