Ethanol-1,1,2,2-d4-amine HCl | CAS 2483832-03-5

OVERVIEW  of  Ethanol-1,1,2,2-d4-amine HCl | CAS 2483832-03-5

Ethanol-1,1,2,2-d₄-amine hydrochloride (CAS 2483832-03-5) is a deuterium-labeled analog of ethanolamine hydrochloride, in which the hydrogen atoms on the carbon backbone are replaced with deuterium. This isotopically labeled compound is a valuable reagent for metabolic studies, mass spectrometric quantitation, and NMR spectroscopy. Its chemical and physical properties are nearly identical to the non-deuterated ethanolamine hydrochloride, allowing it to serve as an ideal internal standard for precise isotopic labeling and quantification in biochemical or pharmaceutical research.

CHEMICAL INFORMATION

• Name: Ethanol-1,1,2,2-d₄-amine hydrochloride

• Molecular Formula: C₂H₄D₄ClNO

• Molecular Weight: 101.57 g/mol

• CAS Number: 2483832-03-5

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated alkanolamine hydrochloride

• Solubility: Freely soluble in water, ethanol, and methanol

APPLICATIONS  of  Ethanol-1,1,2,2-d4-amine HCl | CAS 2483832-03-5

• Mass Spectrometry (MS):
  Extensively used as an internal standard in LC-MS and GC-MS analyses for accurate quantification of ethanolamine and related metabolites in biological matrices.

• Nuclear Magnetic Resonance (NMR):
  Useful in structural elucidation and chemical exchange studies due to its deuterated backbone, which reduces proton interference and improves spectral clarity.

• Pharmaceutical and Metabolic Research:
  Employed as a stable isotope tracer to study ethanolamine metabolism, biosynthetic pathways, and its role in membrane lipid formation.

• Analytical Method Development:
  Facilitates calibration and validation of quantitative analytical techniques by providing a labeled reference standard with identical chemical reactivity.

ADVANTAGES  of  Ethanol-1,1,2,2-d4-amine HCl | CAS 2483832-03-5

• High deuterium enrichment enhances mass spectral resolution and isotopic discrimination.

• Non-radioactive, stable isotope labeling ensures safety and reliability in analytical workflows.

• Chemically and physically equivalent to ethanolamine HCl, enabling consistent comparative analysis.

• Improves signal-to-noise ratio in NMR and MS studies.

HANDLING AND SAFETY

• Handling: Avoid inhalation and direct contact with skin or eyes; handle under a fume hood using proper PPE.

• Storage: Keep tightly sealed in a desiccator at 2–8 °C; protect from moisture and strong oxidizing agents.

• Safety: May cause mild irritation upon contact; wear gloves, goggles, and a lab coat.

• Disposal: Dispose of waste material according to local environmental and safety regulations.

SUMMARY
Ethanol-1,1,2,2-d₄-amine hydrochloride (CAS 2483832-03-5) is a high-purity, deuterium-labeled compound widely utilized in analytical chemistry, metabolic profiling, and isotope dilution assays. Its isotopic labeling provides enhanced analytical precision in MS and NMR applications, making it an essential reference material for researchers studying ethanolamine-related biochemical processes and reaction mechanisms.

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