(±)2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 | CAS 2363789-19-7

OVERVIEW  of  (±)2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 | CAS 2363789-19-7

(±)2-Methyl-d₃-piperazine-2,3,3,5,5,6,6-d₇ (CAS 2363789-19-7) is a highly deuterated analog of 2-methylpiperazine, featuring a total of ten deuterium atoms distributed across the methyl group and the piperazine ring. This stable isotope-labeled compound is primarily used in mass spectrometry (MS), nuclear magnetic resonance (NMR), and pharmaceutical research to enhance analytical precision and distinguish labeled compounds from their non-deuterated counterparts. Its near-identical chemical and physical properties to unlabeled 2-methylpiperazine make it ideal for quantitative isotope dilution, metabolic studies, and pharmaceutical synthesis involving labeled intermediates.

CHEMICAL INFORMATION

• Name: (±)-2-Methyl-d₃-piperazine-2,3,3,5,5,6,6-d₇

• Molecular Formula: C₅D₁₀N₂

• Molecular Weight: 110.23 g/mol

• CAS Number: 2363789-19-7

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic amine

• Solubility: Freely soluble in water, methanol, and ethanol; miscible with most polar solvents

APPLICATIONS  of  (±)2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 | CAS 2363789-19-7

• Mass Spectrometry (MS):
  Used as a stable isotope-labeled internal standard for the quantitative determination of 2-methylpiperazine and related compounds in biological, pharmaceutical, and environmental matrices.

• Nuclear Magnetic Resonance (NMR):
  Serves as a deuterated reference compound that reduces proton background interference, leading to cleaner and higher-resolution spectra.

• Pharmaceutical and Metabolic Research:
  Applied in isotope tracing and kinetic studies to monitor metabolic pathways and transformations involving piperazine-based intermediates.

• Analytical Chemistry:
  Useful for method validation and calibration in isotope dilution assays, ensuring reproducibility and analytical precision.

• Synthetic Chemistry:
  Functions as a deuterated precursor in the preparation of labeled drug intermediates and heterocyclic frameworks for mechanistic or metabolic evaluation.

ADVANTAGES  of  (±)2-Methyl-d3-piperazine-2,3,3,5,5,6,6-d7 | CAS 2363789-19-7

• High isotopic purity ensures accurate isotopic discrimination in analytical studies.

• Non-radioactive and chemically stable, offering long-term reliability in laboratory applications.

• Structurally identical to 2-methylpiperazine, allowing direct experimental comparison.

• Enhances spectral clarity in both MS and NMR analyses.

• Ideal for use in stable isotope labeling and quantitative bioanalytical methods.

HANDLING AND SAFETY

• Handling: Use standard laboratory safety precautions; avoid inhalation and skin contact.

• Storage: Store at 2–8 °C in an airtight container, protected from light and humidity.

• Safety: May cause mild irritation; wear protective gloves, goggles, and a lab coat.

• Disposal: Dispose of in accordance with institutional and regional chemical waste regulations.

SUMMARY
(±)2-Methyl-d₃-piperazine-2,3,3,5,5,6,6-d₇ (CAS 2363789-19-7) is a fully deuterium-labeled heterocyclic amine widely employed in mass spectrometry, NMR spectroscopy, and pharmaceutical research. Its isotopic precision, stability, and compatibility with analytical systems make it an indispensable standard for quantitative analysis, tracer studies, and synthetic labeling applications in modern research and development environments.