Methylamine-d3 HCl | CAS 7436-22-8

OVERVIEW  of  Methylamine-d3 HCl | CAS 7436-22-8

Methylamine-d₃ hydrochloride (CAS 7436-22-8) is a fully deuterated analog of methylamine hydrochloride, in which all three hydrogen atoms of the methyl group are replaced by deuterium. It is a stable, crystalline salt commonly used in isotope labeling, NMR spectroscopy, and mass spectrometry (MS) applications. The hydrochloride form provides enhanced stability and ease of handling compared to gaseous methylamine.

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CHEMICAL INFORMATION

• Name: Methylamine-d₃ hydrochloride

• Molecular Formula: CD₃NH₂·HCl

• Molecular Weight: 75.54 g/mol

• CAS Number: 7436-22-8

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated primary amine salt

• Solubility: Freely soluble in water and polar organic solvents (methanol, ethanol)

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APPLICATIONS  of  Methylamine-d3 HCl | CAS 7436-22-8

• NMR Spectroscopy:
  Used as a deuterated amine standard or solvent additive to eliminate proton interference and improve signal clarity in spectra involving nitrogen-containing compounds.

• Mass Spectrometry (MS):
  Serves as an internal standard or isotopic tracer in quantitative LC-MS or GC-MS analyses, offering reliable isotope differentiation.

• Stable Isotope Labeling:
  Employed in synthesis of deuterium-labeled intermediates for mechanistic and metabolic studies, particularly in pharmaceuticals and biochemical systems.

• Kinetic Isotope Effect Studies:
  Used to probe reaction pathways and hydrogen/deuterium exchange mechanisms, helping elucidate bond-breaking and formation processes.

• Pharmaceutical and Biochemical Research:
  Acts as a building block for deuterated drug analogs and metabolites used in ADME (absorption, distribution, metabolism, and excretion) studies.

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ADVANTAGES  of  Methylamine-d3 HCl | CAS 7436-22-8

• High isotopic enrichment ensures analytical precision.

• Stable, non-volatile salt form allows safe storage and easy measurement.

• Compatible with a wide variety of analytical solvents.

• Reliable reference for isotope-dilution quantification methods.

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HANDLING AND SAFETY

• Handling Precautions: Avoid breathing dust or vapors; handle in a well-ventilated area.

• Protective Equipment: Use gloves, goggles, and protective clothing.

• Storage: Keep sealed under dry, cool conditions; hygroscopic material.

• Stability: Stable under normal laboratory conditions.

• Disposal: Dispose of in accordance with local regulations for amine salts and isotopically labeled compounds.

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SUMMARY
Methylamine-d₃ hydrochloride (CAS 7436-22-8) is a high-purity, fully deuterated primary amine salt widely used in analytical, isotopic, and synthetic research. Its stability, solubility, and isotopic enrichment make it indispensable in NMR and MS analyses, isotopic labeling experiments, and pharmaceutical development, providing accurate and reproducible results in deuterium-based studies.

 

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