Piperazine-2,2,3,3,5,5,6,6-d8 | CAS 134628-42-5

OVERVIEW  of  Piperazine-2,2,3,3,5,5,6,6-d8 | CAS 134628-42-5
Piperazine-2,2,3,3,5,5,6,6-d₈ (CAS 134628-42-5) is a fully ring-deuterated derivative of piperazine, containing eight deuterium atoms substituted for all ring hydrogens. As a stable isotope-labeled compound, it exhibits identical structural and chemical properties to non-deuterated piperazine while providing enhanced analytical traceability. This compound is widely used in mass spectrometry (MS), nuclear magnetic resonance (NMR), and pharmaceutical research for metabolic tracing, isotopic labeling, and quantitative calibration in bioanalytical assays.

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CHEMICAL INFORMATION

• Name: Piperazine-2,2,3,3,5,5,6,6-d₈

• Molecular Formula: C₄D₈N₂

• Molecular Weight: 94.19 g/mol

• CAS Number: 134628-42-5

• Isotopic Enrichment: ≥ 98 atom % D

• Chemical Class: Deuterated heterocyclic amine

• Solubility: Freely soluble in water, ethanol, and most polar solvents

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APPLICATIONS  of  Piperazine-2,2,3,3,5,5,6,6-d8 | CAS 134628-42-5

• Mass Spectrometry (MS):
  Piperazine-2,2,3,3,5,5,6,6-d₈ is extensively used as a mass spectrometric internal standard for the quantification of piperazine or piperazine-derived drugs, providing accurate calibration in both environmental and biological matrices.

• NMR Spectroscopy:
  The absence of proton signals in the ring structure improves spectral clarity, making it ideal for solvent reference or molecular interaction studies involving nitrogen-containing heterocycles.

• Pharmaceutical Research:
  Utilized in drug metabolism and pharmacokinetic studies, this deuterated analog enables precise tracing of piperazine-derived moieties in therapeutic compounds such as antihistamines, antipsychotics, and antiparasitic drugs.

• Isotopic Labeling and Mechanistic Studies:
  Serves as a stable isotope tracer in investigations of reaction pathways, enzymatic transformations, and hydrogen–deuterium exchange kinetics, aiding in understanding chemical and biological mechanisms.

• Synthetic Intermediate:
  Acts as a deuterated precursor for the preparation of labeled pharmaceuticals, metabolites, and reference standards in analytical chemistry and industrial synthesis.

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ADVANTAGES  of  Piperazine-2,2,3,3,5,5,6,6-d8 | CAS 134628-42-5

• High isotopic purity ensures reliable analytical accuracy.

• Non-radioactive, safe, and environmentally stable isotope label.

• Chemically identical to native piperazine, ensuring compatibility in comparative studies.

• Enhances precision in LC-MS/MS and NMR analyses.

• Suitable for both laboratory-scale and industrial research applications.

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HANDLING AND SAFETY

• Handling: Use under well-ventilated conditions and avoid inhalation, ingestion, or prolonged contact with skin or eyes.

• Protective Equipment: Gloves, safety goggles, and lab coats are recommended.

• Storage: Store in a tightly closed container in a cool, dry, and well-ventilated area. Avoid exposure to strong oxidizing agents.

• Stability: Stable under standard laboratory conditions; does not readily degrade.

• Disposal: Dispose of in accordance with institutional and regional chemical waste management procedures.

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SUMMARY
Piperazine-2,2,3,3,5,5,6,6-d₈ (CAS 134628-42-5) is a highly deuterated, stable isotope-labeled analog of piperazine, designed for advanced analytical and research applications. Its complete ring deuteration and chemical equivalence to the native molecule make it an essential tool in mass spectrometry calibration, NMR spectroscopy, and metabolic investigations. With its high purity, reliability, and safety profile, this compound plays a crucial role in pharmaceutical, biochemical, and mechanistic studies requiring precise isotopic labeling and analytical accuracy.

 

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